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NFL Week 4 betting: Odds, lines and totals for every game
Esports

NFL Week 4 betting: Odds, lines and totals for every game

by admin September 22, 2025



Sep 22, 2025, 12:58 PM ET

Week 4 gets underway with a matchup of NFC West rivals when the Arizona Cardinals host the Seattle Seahawks on “Thursday Night Football.”

Sunday night features Micah Parsons and the Green Bay Packers hitting the road to take on the Dallas Cowboys.

The week wraps up with a “Monday Night Football” doubleheader as the New York Jets visit the Miami Dolphins (7:15 ET on ESPN) and the Denver Broncos host the Cincinnati Bengals (8:15 on ABC).

Here’s a look at the odds for every Week 4 game.

Odds as of publication time. For the most current odds, visit ESPN BET.

Jump to:
SEA-ARI | MIN-PIT | NO-BUF | LAC-NYG
WSH-ATL | PHI-TB | CLE-DET | CAR-NE
TEN-HOU | JAX-SF | IND-LAR | CHI-LV
BAL-KC | GB-DAL | NYJ-MIA | CIN-DEN

Seattle Seahawks vs. Arizona Cardinals -1.5
Thursday, 8:15 p.m., Prime Video

Money line: Seahawks (-105); Cardinals (-115)
Total: 43.5; Opened: 44.5
FPI favorite: Cardinals by 0.8 with a 52.47% probability to win outright

Minnesota Vikings -2.5 vs. Pittsburgh Steelers
Sunday, 9:30 a.m., NFL Net, NFL+

Money line: Vikings (-150); Steelers (+130)
Total: 40.5; Opened: 41.5
FPI favorite: Vikings by 3.1 with a 57.18% probability to win outright

New Orleans Saints vs. Buffalo Bills -15.5
Sunday, 1 p.m., CBS

Money line: Saints (+900); Bills (-1800)
Total: 47.5; Opened: 48.5
FPI favorite: Bills by 13.3 with a 79.67% probability to win outright

Los Angeles Chargers -6.5 vs. New York Giants
Sunday, 1 p.m., CBS

Money line: Chargers (-280); Giants (+230)
Total: 44.5; Opened: 45.5
FPI favorite: Chargers by 6.8 with a 67.8% probability to win outright

Washington Commanders -2.5 vs. Atlanta Falcons
Sunday, 1 p.m., CBS

Money line: Commanders (-145); Falcons (+125)
Total: 44.5; Opened: 46.5
FPI favorite: Commanders by 3.8 with a 59.33% probability to win outright

Philadelphia Eagles -3.5 vs. Tampa Bay Buccaneers
Sunday, 1 p.m., Fox

Money line: Eagles (-170); Buccaneers (+145)
Total: 44.5; Opened: 45.5
FPI favorite: Eagles by 1.7 with a 54.6% probability to win outright

Cleveland Browns vs. Detroit Lions -8.5
Sunday, 1 p.m., Fox

Money line: Browns (+360); Lions (-500)
Total: 45.5; Opened: 45.5
FPI favorite: Lions by 10.8 with a 75.73% probability to win outright

Carolina Panthers vs. New England Patriots -5.5
Sunday, 1 p.m., Fox

Money line: Panthers (+195); Patriots (-230)
Total: 43.5; Opened: 44.5
FPI favorite: Patriots by 2.4 with a 56.07% probability to win outright

Tennessee Titans vs. Houston Texans -6.5
Sunday, 1 p.m., CBS

Money line: Titans (+280); Texans (-360)
Total: 39.5; Opened: 39.5
FPI favorite: Texans by 7.9 with a 69.67% probability to win outright

Jacksonville Jaguars vs. San Francisco 49ers -3.5
Sunday, 4:05 p.m., Fox

Money line: Jaguars (+150); 49ers (-175)
Total: 46.5; Opened: 45.5
FPI favorite: 49ers by 0.3 with a 50.07% probability to win outright

Indianapolis Colts vs. Los Angeles Rams -3.5
Sunday, 4:05 p.m., Fox

Money line: Colts (+160); Rams (-190)
Total: 48.5; Opened: 48.5
FPI favorite: Rams by 2.6 with a 57.2% probability to win outright

Chicago Bears vs. Las Vegas Raiders -1.5
Sunday, 4:25 p.m., CBS

Line movement: Opened Bears -1.5

Money line: Bears (-105); Raiders (-115)
Total: 47.5; Opened: 47.5
FPI favorite: Bears by 0.6 with a 51.6% probability to win outright

Baltimore Ravens -2.5 vs. Kansas City Chiefs
Sunday, 4:25 p.m., CBS

Money line: Ravens (-150); Chiefs (+130)
Total: 48.5; Opened: 48.5
FPI favorite: Ravens by 0.6 with a 50.98% probability to win outright

Green Bay Packers -6.5 vs. Dallas Cowboys
Sunday, 8:20 p.m., NBC

Money line: Packers (-275); Cowboys (+225)
Total: 47.5; Opened: 48.5
FPI favorite: Packers by 3.5 with a 58.8% probability to win outright

New York Jets vs. Miami Dolphins -2.5
Monday, 7:15 p.m., ESPN

Money line: Jets (+120); Dolphins (-140)
Total: 45.5; Opened: 44.5
FPI favorite: Dolphins by 2.3 with a 56.8% probability to win outright

Cincinnati Bengals vs. Denver Broncos -7.5
Monday, 8:15 p.m., ABC

Money line: Bengals (+290); Broncos (-380)
Total: 44.5; Opened: 44.5
FPI favorite: Broncos by 8.8 with a 72% probability to win outright



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