NFL

The Week 5 NFL schedule for the 2025 season brings some exciting matchups.

Browns rookie QB Dillon Gabriel is making his NFL debut in London against the Vikings. Old teammates in Carolina, QBs Baker Mayfield and Sam Darnold, will face off again in the Bucs-Seahawks matchup. And Commanders QB Jayden Daniels makes his return from injury against the Chargers.

We have you covered with everything you need to know. Our NFL Nation reporters take you inside the locker room with the best thing they heard this week, and ESPN Research provides a key stat to know and a betting nugget for each contest. Plus, analytics writer Seth Walder makes a bold prediction for each matchup, and fantasy analyst Eric Moody shares fantasy football intel. We also have Football Power Index (FPI) matchup quality ratings (out of 100) and game projections, and three analysts — Pamela Maldonado, Moody and Walder — give us final score picks for every game.

Let’s get into the full Week 5 slate, which culminates with a “Monday Night Football” matchup between the Chiefs and Jaguars on ESPN. (Game times are Sunday unless otherwise noted.)

Jump to a matchup:
CLE-MIN | DEN-PHI | HOU-BAL
LV-IND | DAL-NYJ | MIA-CAR
NYG-NO | TB-SEA | TEN-ARI
WSH-LAC | DET-CIN | NE-BUF
KC-JAX

Thursday: SF 26, LAR 23 (OT)
Bye: ATL, CHI, GB, PIT

9:30 a.m. ET | NFL Network | Matchup rating: 35.2/100
ESPN BET: MIN -3.5 (35.5 O/U)

What we’re hearing on the Browns: The Browns are turning to rookie QB Dillon Gabriel in hopes of jump-starting the league’s second-lowest-scoring offense (14 points per game). Gabriel’s first start comes in a bit of an unusual spot — he will become the first quarterback to make his first start in an international game — but Cleveland believes the third-round pick has prepared well for the moment. Expect the Browns to increase their use of rollouts and RPOs to take advantage of Gabriel’s mobility and accuracy. “[Gabriel] knows where to go with the ball. He knows what the coaching staff wants within the offense,” wide receiver Jerry Jeudy said. — Daniel Oyefusi

What we’re hearing on the Vikings: The Vikings spent their week in London sorting through options for an injury-ravaged offensive line, a particularly concerning development given the strength of the Browns’ defensive front. At the very least, the Vikings will be without RT Brian O’Neill (right knee), C Ryan Kelly (concussion) and LG Donovan Jackson (left wrist). Backup C Michael Jurgens (hamstring) sat out practice Wednesday and Thursday, making him very questionable for Sunday’s game. In a worst-case scenario, the Vikings could be left with their No. 3 center, their No. 3 left guard and their No. 2 right tackle against a defense that leads the NFL in pass rush win rate (56%) and run stop win rate (37.7%). — Kevin Seifert

Editor’s Picks

2 Related

Stat to know: The Browns have scored 17 or fewer points in nine straight games dating to last season, which is tied for the longest streak in franchise history. — ESPN Research

Bold prediction: Browns DT Mason Graham will record his first full sack as a pro. It’s hard to get a better opportunity than this, as QB Carson Wentz has taken sacks at a massive 11.5% clip so far this season. — Walder

Injuries: Browns | Vikings

Fantasy nugget: Vikings RB Jordan Mason has had 16 or more touches in consecutive games with Aaron Jones Sr. (hamstring) out. The good news: He’s seeing heavy usage. The bad news: The Vikings’ offensive line has been devastated by injuries and faces a Browns defensive front that previously shut down the Ravens’ Derrick Henry and the Packers’ Josh Jacobs. Cleveland’s defense has allowed just 2.9 yards per carry and the second-fewest rushing yards to backs. See Week 5 rankings. — Moody

Betting nugget: The Vikings are 14-7 ATS (against the spread) in their past 21 road/neutral games. Read more. — ESPN Research

Maldonado’s pick: Browns 24, Vikings 19
Moody’s pick: Vikings 20, Browns 14
Walder’s pick: Browns 18, Vikings 15
FPI prediction: MIN, 62.9% (by an average of 4.8 points)

Matchup must-reads: Browns bench Flacco, turn to Gabriel as starting QB … Vikings’ plan for week between Dublin and London … Vikings’ O’Neill, Kelly injured against Steelers

1 p.m. ET | CBS | Matchup rating: 77.8/100
ESPN BET: PHI -3.5 (43.5 O/U)

What we’re hearing on the Broncos: QB Bo Nix has had many weekly exams in his time as the starter. And this week Nix’s patience will be tested as much as it ever has against an Eagles defense directed by coordinator Vic Fangio. Fangio, who again has two rookie starters on defense (LB Jihaad Campbell and S Andrew Mukuba), will force Nix to live with the underneath throws. Before last week’s win, Nix had not found much success pushing the ball downfield to kick-start the offense. Nix was more settled Monday night, with better footwork and more patience. That will be a necessity in this one as well, given Fangio figures to give Nix a steady diet of simulated pressures and coverage looks that morph after the snap. Fangio has been a particular challenge to quarterbacks in the red zone. — Jeff Legwold

What we’re hearing on the Eagles: The Eagles need to get WR A.J. Brown going. He was held to two catches for 7 yards on nine targets last week and created a stir with a cryptic tweet postgame. Brown has been held to 27 or fewer yards in three of four games. Unsurprisingly, the passing game ranks 31st in the NFL. “I see that we’re struggling and I’m a guy that wants the ball in those times when we can’t find a way. Give it to me,” Brown said Wednesday. — Tim McManus

Stat to know: The Broncos’ defense ranks first in QBR (40.5) and sacks (15), as well as second in pressures (62). — ESPN Research

Bold prediction: Broncos edge Jonathon Cooper will record a sack against Eagles RT Lane Johnson. That’s a tall task considering the opposition, but Cooper has the fastest pass rush get-off in the NFL (among those with at least 50 pass rushes), crossing the line of scrimmage in 0.69 seconds, per NFL Next Gen Stats. — Walder

play

1:37

Stephen A. isn’t buying A.J. Brown’s claims about his lack of targets

Stephen A. Smith questions whether A.J. Brown’s concerns surrounding his target share are valid.

Injuries: Broncos | Eagles

Fantasy nugget: Eagles TE Dallas Goedert posted a season-high 19.7 fantasy points in Week 4, despite seeing just four targets. He had only two targets in Week 1, missed Week 2 and saw just two in Week 3, yet he has totaled 41.4 fantasy points. Even though the Broncos’ defense is tough, Denver has allowed at least 10 fantasy points to tight ends in two of its past three games. See Week 5 rankings. — Moody

Betting nugget: The Eagles are 9-3 ATS in their past 12 games as favorites. Read more. — ESPN Research

Maldonado’s pick: Eagles 13, Broncos 10
Moody’s pick: Eagles 27, Broncos 23
Walder’s pick: Broncos 23, Eagles 21
FPI prediction: PHI, 61.2% (by an average of 4.2 points)

Matchup must-reads: Jones’ endless energy catalyst for Broncos’ defense … Inside the champagne problems of the Eagles offense

1 p.m. ET | CBS | Matchup rating: 64.9/100
ESPN BET: HOU -2.5 (40.5 O/U)

What we’re hearing on the Texans: The Texans know they’re going against a foe that they’ve struggled with. The Ravens have a 13-2 record against Houston, but coach DeMeco Ryans said, “The past is the past.” Wideout Nico Collins acknowledged the 31-2 blowout loss they suffered on Christmas to Baltimore but said it’s time to “turn the page.” — DJ Bien-Aime

What we’re hearing on the Ravens: The Ravens are 3-0 against Texans QB C.J. Stroud, holding him to an average of seven points per game. But this is expected to be a much different Baltimore defense Sunday. The Ravens have six defensive starters dealing with injuries, including Pro Bowlers in S Kyle Hamilton (groin), MLB Roquan Smith (hamstring) and CB Marlon Humphrey (calf). With all the new players filling in on defense, OLB Tavius Robinson said, “It’s just about doing a little extra in communication.” — Jamison Hensley

Stat to know: The Ravens have allowed 35 points in three of four games this season, tied for the most such games in a season in franchise history (1996 and 2021). — ESPN Research

Bold prediction: Ravens RB Derrick Henry will record a season-high 22-plus rush attempts. The Texans have a ferocious pass rush but struggle to stop the run. QB Lamar Jackson (hamstring) could be out, so the Ravens are going to want to lean on the ground game. — Walder

play

1:07

Why Dan Orlovsky says Ravens-Texans is a must-win for Baltimore

Dan Orlovsky rips the Ravens and explains why Sunday’s game against the Texans is a must-win, even if Lamar Jackson is sidelined.

Injuries: Texans | Ravens

Fantasy nugget: Texans RB Woody Marks capitalized on a favorable matchup against Tennessee last week, finishing with 21 touches and 27.9 fantasy points. It was the first game in which he out-touched Nick Chubb. He made it count, putting up an outstanding performance despite a Texans offensive line that ranks 24th in run block win rate (68.8%). The good news? Marks has another favorable matchup this week against a Ravens defense that has allowed the sixth-most rushing yards per game to backs (141.3). See Week 5 rankings. — Moody

Betting nugget: The Texans are the only team to go under the total in all four games this season, and the Ravens are the only team to go over the total in every game. Read more. — ESPN Research

Maldonado’s pick: Ravens 23, Texans 14
Moody’s pick: Ravens 23, Texans 20
Walder’s pick: Ravens 20, Texans 17
FPI prediction: BAL, 56.0% (by an average of 2.2 points)

Matchup must-reads: Emergence of rookie RB Marks gives spark to Texans … How the Ravens got to 1-3 and where they go from here … Texans look to beat Ravens for first time since 2014 … What’s wrong with the 1-3 Ravens? Injuries, consistency, more

1 p.m. ET | Fox | Matchup rating: 48.6/100
ESPN BET: IND -6.5 (47.5 O/U)

What we’re hearing on the Raiders: The offensive line is coming off its best performance of the season, but it took a big hit in the process. After the unit allowed just three pressures while paving the way for rookie RB Ashton Jeanty to record 138 yards, it lost starting LT Kolton Miller to a high ankle sprain. Miller’s absence is untimely since the Colts are ranked eight in rushing yards allowed per game (96). Coach Pete Carroll is confident that backup OT Stone Forsythe can step up. “He started 14 games … and started on the left side four or five times. So, we’re confident that he can do the job,” Carroll said. “That’s why we went after him.” — Ryan McFadden

What we’re hearing on the Colts: Indianapolis has had one of the most efficient offenses this season, ranking fourth in scoring at 30.8 points per game. But that comes in spite of its concerning performance in the red zone, where the Colts have managed to score touchdowns only 47.4% of the time (25th in the NFL). They’ve had a rash of ill-timed penalties when in scoring position, and that has led to difficult down-and-distance situations. “We’ve got to get that cleaned up, and it’s just fundamentals and technique,” coach Shane Steichen said. “We’ll address it through practice this week.” — Stephen Holder

Stat to know: Colts rookie Tyler Warren leads all tight ends in receiving yards this season (263), which is the most for the position through four career games in the Super Bowl era. — ESPN Research

Bold prediction: Raiders TE Brock Bowers will record under 30 receiving yards. Bowers hasn’t put up big numbers since injuring his knee in Week 1, and the Colts look like a particularly tough opponent. Only 14% of targets against Indianapolis have gone to tight ends, the fourth-lowest rate in the league. — Walder

All of ESPN. All in one place.

Watch your favorite events in the newly enhanced ESPN App. Learn more about what plan is right for you. Sign Up Now

Injuries: Raiders | Colts

Fantasy nugget: Colts WR Michael Pittman Jr. has scored 15 or more fantasy points in three of four games this season while averaging 7.2 targets. He’s set up for a huge performance against a defense that has allowed the third-most fantasy points per game to wide receivers. See Week 5 rankings. — Moody

Betting nugget: The Raiders are 0-3 ATS in their past three games. Read more. — ESPN Research

Maldonado’s pick: Colts 34, Raiders 28
Moody’s pick: Colts 34, Raiders 24
Walder’s pick: Colts 26, Raiders 21
FPI prediction: IND, 63.9% (by an average of 5.3 points)

Matchup must-reads: Why Booker IV and the Raiders’ D-line will be critical to a win in Indianapolis … Howard abruptly retires, citing ‘family first’

1 p.m. ET | Fox | Matchup rating: 39.7/100
ESPN BET: DAL -2.5 (47.5 O/U)

What we’re hearing on the Cowboys: Didn’t the Cowboys come off a 40-point performance at home, playing at a winless team just two weeks ago? They did. And lost to the Bears in a listless performance. Now coming off a 40-point performance against the Packers, they face the winless Jets. In 2019, the Jets were also 0-4 when facing the Cowboys, and Dallas lost 24-22. The Cowboys can’t repeat what happened to the Bears or what happened in 2019. “We’re judged on wins. I’d say the consistency’s not been there,” coach Brian Schottenheimer said. “The thing we’ve got to do, we’ve got to learn how to finish and how to win.” — Todd Archer

What we’re hearing on the Jets: The gloves are going on — literally. On Thursday, coach Aaron Glenn wore a boxing glove during a ball-security drill, trying to punch out the ball. The Jets have lost a league-high six fumbles, which explains the emphasis in practice. The Jets are a mistake-prone team — minus-seven turnover differential and 40 penalties (tied-seventh most). They’re seeking to avoid their third 0-5 start in the past 30 years. — Rich Cimini

Stat to know: The Jets have allowed 25-plus points in every game this season (the only team in the NFL to do so). Another such game will be tied for the longest streak of allowing 25-plus points in a season in franchise history. — ESPN Research

Bold prediction: Cowboys LB Jack Sanborn will lead the league in tackles this week. The Jets are running at an outrageous clip and are currently sporting a league-low minus-12% pass rate over expectation. As only light underdogs to Dallas, they very well could stick with the ground game for 60 minutes, inducing tons of tackling opportunities for Cowboys linebackers. — Walder

Injuries: Cowboys | Jets

Fantasy nugget: Jets QB Justin Fields finished with 27.1 fantasy points last week and now faces a defense that has allowed the most fantasy points per game to quarterbacks. Dallas has also given up the most rushing attempts and the fifth-highest rushing yards per game to opposing quarterbacks. See Week 5 rankings. — Moody

Betting nugget: Cowboys QB Dak Prescott is 21-14-1 ATS in his career as a road favorite (49-36-2 ATS overall as the favorite). Read more. — ESPN Research

Maldonado’s pick: Jets 24, Cowboys 21
Moody’s pick: Jets 24, Cowboys 23
Walder’s pick: Cowboys 30, Jets 23
FPI prediction: DAL, 63.9% (by an average of 3.5 points)

Matchup must-reads: Pickens keeps impressing Cowboys on, off the field … Jets RB Allen out indefinitely with knee injury … Prescott set Cowboys records but is unsatisfied with tie … Glenn hoping to avoid being first 0-5 Jets coach in Year 1

1 p.m. ET | Fox | Matchup rating: 24.6/100
ESPN BET: MIA -1.5 (44.5 O/U)

What we’re hearing on the Dolphins: Tyreek Hill (knee) will not return this season, but the Dolphins believe they still have a No. 1 receiver in Jaylen Waddle — who returns to that unquestioned role in Hill’s absence. Waddle was Miami’s leading receiver as a rookie in 2021, when he caught 104 passes for 1,015 yards and six touchdowns. Coach Mike McDaniel said the view of Waddle doesn’t change despite Hill’s injury. “I think we’ve looked at him as a wide receiver one,” McDaniel said. “I think that it’s not necessarily a change from the way we approach it the way we see it.” — Marcel Louis-Jacques

What we’re hearing on the Panthers: Coach Dave Canales likes to look at the rash of injuries that have contributed to a 1-3 record as an opportunity for someone else to step up. Unfortunately for him, nobody has. Perhaps it will be rookie WR Jimmy Horn Jr., who will play for the first time after being a healthy scratch the first four games. He brings speed. Or maybe it will be starting WR Xavier Legette, returning after missing two games with a hamstring injury, even though he struggled before the injury. There are plenty of opportunities around. — David Newton

Stat to know: Dolphins QB Tua Tagovailoa has a Total QBR of 19 (33rd) and averages 6.3 yards per attempt (25th) when facing zone coverage this season. The Panthers use zone coverage 68.8% of the time, the seventh-highest rate in the league this season. — ESPN Research

Bold prediction: Panthers WR Tetairoa McMillan will catch multiple passes of 15 air yards or more after having caught exactly one such pass in each of his first four games. The Dolphins’ defense is allowing 9.6 air yards per attempt, second most in the league. — Walder

play

3:11

Inside the anatomy of Tyreek Hill’s knee injury with Stephania Bell

Using Virtual Medicine, Stephania Bell examines Tyreek Hill’s season-ending knee injury from an anatomical perspective.

Injuries: Dolphins | Panthers

Fantasy nugget: Since the Dolphins acquired Hill in 2022, 76% of QB Tagovailoa’s completions and 82% of his wide receiver yards have gone to Hill or Waddle. In the only game Miami has played without Hill during that span, Waddle caught eight passes for 142 yards and a touchdown. He should once again see plenty of targets against the Panthers. See Week 5 rankings. — Moody

Betting nugget: The Panthers have covered four straight games following a loss (2-0 ATS this season). They are 7-1 ATS in their past eight games following a loss. Read more. — ESPN Research

Maldonado’s pick: Panthers 33, Dolphins 27
Moody’s pick: Panthers 31, Dolphins 28 
Walder’s pick: Panthers 23, Dolphins 20
FPI prediction: CAR, 51.3% (by an average of 0.5 points)

Matchup must-reads: WR Hill dislocates knee in win against Jets … Panthers seek answers after embarrassing loss to Patriots … Hill injury FAQ: Recovery timetable, his NFL future, how Miami will adapt

1 p.m. ET | CBS | Matchup rating: 19.6/100
ESPN BET: NO -1.5 (41.5 O/U)

What we’re hearing on the Giants: The Giants are pumping in crowd noise and working on communication at practice throughout the week, especially with this being rookie QB Jaxson Dart’s first career road game. But Dart noted he played in the SEC and has played in a dome before. He’s not looking at the Superdome as any kind of special challenge. He’s more concerned with getting the ball out quicker, getting through his progressions better and avoiding sacks against a Saints defense that has gotten home on a respectable 10% of dropbacks. — Jordan Raanan

What we’re hearing on the Saints: Saints TEs Foster Moreau and Taysom Hill returned to practice this week for the first time since last season, when both sustained serious knee injuries. Though it’s unlikely either will play this weekend, coach Kellen Moore didn’t rule it out completely. Getting both players back will be a big boost to the offense. “With 108 seconds left in the 2024 season, I got a helmet to the outside of the knee on a five-step out route, and my offseason is canceled,” Moreau said. “It’s brutal, and that part of sports is one of the hardest parts. But what doesn’t kill you makes you stronger. And I’ve had a hell of an offseason.” — Katherine Terrell

Stat to know: Giants RB Cam Skattebo has 181 rushing yards and 98 receiving yards through four career games. If he has a productive day Sunday, Skattebo would be the fourth Giants rookie since the 1970 merger with 200 rushing yards and 100 receiving yards through five career games. — ESPN Research

Weekly NFL game expert picks

• Game picks from our NFL experts »
• Betting notes » | More NFL coverage »

Bold prediction: The Giants will deliver double-digit quarterback hits in a win Sunday. After a bit of a slow start, edge rusher Abdul Carter looked dominant last week, and now the Giants face a Saints team that ranks 29th in pass block win rate (51.9%). — Walder

Injuries: Giants | Saints

Fantasy nugget: Dart finished with 19.8 fantasy points last week, with 11.4 of those points coming from rushing. This is a great matchup for Dart, Wan’Dale Robinson and Darius Slayton against a defense that has allowed the fifth-most fantasy points per game to quarterbacks. See Week 5 rankings. — Moody

Betting nugget: Saints QB Spencer Rattler is 0-10 outright and 2-8 ATS in his career as a starter. Read more. — ESPN Research

Maldonado’s pick: Saints 23, Giants 20
Moody’s pick: Saints 20, Giants 18
Walder’s pick: Giants 23, Saints 16
FPI prediction: NO, 53.5% (by an average of 1.4 points)

Matchup must-reads: Dart on Saints draft snub: ‘Always a chip on your shoulder’ … Saints ‘got to find a way to get a win’ with Giants looming

4:05 p.m. ET | CBS | Matchup rating: 57.7/100
ESPN BET: SEA -3.5 (45.5 O/U)

What we’re hearing on the Buccaneers: The Bucs have surrendered touchdowns on the first defensive possession in three of their four games, but have only scored on the first offensive possession once. That is a big reason why they’ve had to come from behind in the final two minutes of their games, which have all been decided by one score or less. QB Baker Mayfield said of this week’s game: “[We’ve] got to start faster, [we’ve] got to be the aggressor, not wait [for] whether it’s chippy or we get hit in the mouth once. We’ve got to come out swinging.” — Jenna Laine

What we’re hearing on the Seahawks: Coach Mike Macdonald said that by the Seahawks’ in-house metrics, Mayfield is probably the best quarterback in the NFL right now in terms of extended-play situations. “That’s something you have to deal with, but he also plays on time,” Macdonald said. “He’s extremely accurate, he’s got a great arm, and then when he extends plays, obviously he’s a great competitor.” Mayfield has the eighth-fastest average time before throw at 2.68 seconds. — Brady Henderson

Stat to know: The Bucs have scored and allowed an identical 97 points so far this season. — ESPN Research

Bold prediction: Seahawks edge Boye Mafe will record a 25% pass rush win rate — or better. When DeMarcus Lawrence (quadriceps) got hurt in last week’s game, Mafe moved to play more opposite the right tackle. That’s where you want to be against the Bucs right now, with Charlie Heck (80% pass block win rate) currently stationed there. Assuming Lawrence either misses the game or plays less, that should set up Mafe to make a pass-rushing impact. — Walder

play

1:20

Smith-Njigba on Seattle’s offense: Darnold has been next level

Seahawks WR Jaxon Smith-Njigba joins “The Rich Eisen Show” to explain why Seattle’s offense has started to click this season.

Injuries: Buccaneers | Seahawks

Fantasy nugget: Seahawks QB Sam Darnold has averaged 16.2 fantasy points over his past three games in an offense that ranks fourth in rushing attempts per game. Seattle may need to lean on the passing game against a defensive front that allows the fewest rushing yards to running backs, but Tampa Bay also gives up the eighth-most fantasy points to quarterbacks. See Week 5 rankings. — Moody

Betting nugget: The Bucs are 6-1 ATS after a loss since the start of last season, and 11-4 ATS after a loss with Mayfield (since 2023). Read more. — ESPN Research

Maldonado’s pick: Seahawks 35, Buccaneers 25
Moody’s pick: Seahawks 26, Buccaneers 24
Walder’s pick: Seahawks 27, Buccaneers 17
FPI prediction: SEA, 53.9% (by an average of 1.5 points)

Matchup must-read: Seahawks sign Darnold’s praises after game-winning drive

4:05 p.m. ET | CBS | Matchup rating: 25.2/100
ESPN BET: ARI -7.5 (42.5 O/U)

What we’re hearing on the Titans: The Titans’ defense will do its best to keep Cardinals QB Kyler Murray from breaking off long runs by design or circumstance. Defensive coordinator Dennard Wilson said the pass rush has to be coordinated and disciplined to make sure the defense doesn’t leave an escape lane for Murray to leak through. “He tries to get outside the pocket, they have some options with him,” Wilson said. “Things like that with the run pass option and all those things, so we got to keep ’em in a well, we got to contain ’em.” — Turron Davenport

What we’re hearing on the Cardinals: Murray is trying to keep his head down and focus on the present with the state of the Cardinals’ offense, which struggled mightily in seven of its past eight quarters. Aside from the fourth quarter in a loss to the Seahawks last Thursday night, Arizona’s offense struggled to move the ball and score in Weeks 3 and 4. But Murray said it’s hard and the “human in me” wants to look at the totality of Arizona’s issues, but focusing on today takes discipline, he said. “I try not to look at the big picture, because s— gets you get frustrated looking at the big picture,” Murray said. — Josh Weinfuss

Stat to know: Titans QB Cam Ward has been sacked an NFL-high 17 times this season, while the Cardinals rank fifth in pass rush win rate this season (47%). — ESPN Research

Bold prediction: Cardinals RB Michael Carter will record 80 or more rushing yards. It’s hard to know exactly how the Cardinals’ backfield work will shake out in light of Trey Benson’s move to IR, but whoever gets the rush attempts should be put in a great position for success: The Titans rank fourth worst in terms of EPA allowed per opponent rush (.09). — Walder

Injuries: Titans | Cardinals

Fantasy nugget: The Cardinals’ backfield is thin with Benson (knee) and James Conner out. Emari Demercado is now positioned to lead the Cardinals’ running back committee. He’s firmly on the flex radar in Week 5 against a Titans defense that allows the fourth-most fantasy points to backs. See Week 5 rankings. — Moody

Betting nugget: The Titans are 3-18 ATS under Brian Callahan, the worst record for any coach in the Super Bowl era (min. five games). Read more. — ESPN Research

Maldonado’s pick: Cardinals 28, Titans 23
Moody’s pick: Cardinals 27, Titans 16
Walder’s pick: Cardinals 28, Titans 14
FPI prediction: ARI, 73.4% (by an average of 9.7 points)

Matchup must-reads: Despite 0-4 start, Titans still believe they can right ship … Cardinals need to fill void in injury-depleted running back room … Ward vents frustration after Titans blanked, fall to 0-4 … Harrison keeping trust in self amid inconsistencies

4:25 p.m. ET | Fox | Matchup rating: 71.3/100
ESPN BET: LAC -2.5 (48.5 O/U)

What we’re hearing on the Commanders: Washington’s defense continues to be plagued by explosive plays, having allowed an NFL-worst 28 pass plays of 15 yards or more. It has been a combination of mistakes: communication and players abandoning assignments trying to make a big play. They’ll have to guard Chargers QB Justin Herbert, who ranks 11th with 20 pass plays of at least 15 yards. Of those plays, he has completed seven with three touchdowns to WR Quentin Johnston. “If we clean up the explosive passes, we’re playing solid,” said defensive coordinator Joe Whitt Jr. “Right now we’re playing sloppy. We will clean it up.” — John Keim

What we’re hearing on the Chargers: After a game where Herbert was hit 13 times and sacked twice, the Chargers could be without two starting offensive linemen again Sunday. LT Joe Alt (ankle) is doubtful for Sunday, and RG Mekhi Becton (concussion) didn’t play last week. “Just go out there and execute and do what you’ve been trained to do,” Herbert said of his message to backups. “They’re playmakers, too.” — Kris Rhim

Stat to know: This will be a staunch matchup in the red zone. The Commanders have scored touchdowns on seven of nine such drives (78%). The Chargers have allowed touchdowns on four of 13 such drives (31%). — ESPN Research

Bold prediction: Commanders QB Jayden Daniels will complete fewer than 10 passes to wide receivers. Chargers CBs Donte Jackson and Tarheeb Still both rank in the top five in lowest yards per coverage snap allowed among outside corners with at least 100 coverage snaps, per NFL Next Gen Stats. That will make throwing outside difficult in any circumstance, and even more with Washington missing WR Terry McLaurin (quadriceps) because of injury. — Walder

Best of NFL Nation

• How the 49ers rebuilt roster around Purdy
• Rams WR Puka Nacua is hammer, not nail
• Aaron Glenn, Jets hoping to avoid being 0-5
• Saints trying to find a way to get a win
• Rules change leads to most returns in history

Injuries: Commanders | Chargers

Fantasy nugget: Herbert struggled to capitalize in a favorable matchup against the Giants, finishing with a season-low 12.5 fantasy points. However, his fortunes (and those of fantasy managers) could change against the Commanders, who have allowed the seventh-most fantasy points per game to quarterbacks. Herbert also has an elite trio of receivers in Johnston, Ladd McConkey and Keenan Allen, who should help him bounce back. See Week 5 rankings. — Moody

Betting nugget: Three straight Chargers games have gone under the total. Read more. — ESPN Research

Maldonado’s pick: Chargers 20, Commanders 10
Moody’s pick: Chargers 27, Commanders 21
Walder’s pick: Chargers 30, Commanders 17
FPI prediction: LAC, 58.2% (by an average of 3.1 points)

Matchup must-reads: QB Daniels (knee) plans to play vs. Chargers … Alt doubtful to play Sunday, Harbaugh says … Commanders’ D focused on execution after flop vs. Falcons … Chargers’ Harbaugh: Hits Herbert taking ‘very concerning’

4:25 p.m. ET | Fox | Matchup rating: 66.0/100
ESPN BET: DET -10.5 (49.5 O/U)

What we’re hearing on the Lions: It’ll be an emotional homecoming for Lions RB David Montgomery as he plays in his hometown for the first time in his NFL career. He played the Bengals once in 2021 with the Bears in Chicago (20 rushes, 61 yards), but he has never had a road game against the Bengals. Montgomery attended Mount Healthy (Ohio) High School, where he earned All-State honors as a dual-threat QB. He is coming off a season-low 12 rushing yards with nine carries against Cleveland, but is looking to get back on track in a familiar setting in front of family and friends. “He’s going to kill it,” Arvie Crouch, Montgomery’s high school coach, told ESPN. — Eric Woodyard

What we’re hearing on the Bengals: This game will be a gut check for the Bengals in every way possible. The Lions are expected to steamroller Cincinnati, which is in some of the worst form in franchise history. Detroit is second in the NFL in rate of designed rush plays, per ESPN Research. The Bengals’ rush defense will have to limit big plays, and stopping those will come down to deploying basic techniques. Said defensive coordinator Al Golden: “Just defend your gap, keep the ball on your inside pad. Play with leverage.” — Ben Baby

Stat to know: Bengals WR Ja’Marr Chase is seeking to avoid going three straight games with 50 or fewer receiving yards for the second time in his career. — ESPN Research

Bold prediction: Bengals QB Jake Browning will record a 60-plus QBR. Don’t get me wrong: Confidence in Browning has dropped off dramatically from where it was a few weeks ago. But then again, the two defenses he has played have been the Vikings and Broncos, and it doesn’t get much tougher than that. Considering his past success, I think there’s still hope for him and the Bengals. — Walder

play

1:49

Stephen A.: Bengals’ season is a ‘wash’ without Burrow

Stephen A. Smith breaks down the struggles facing the Bengals with star quarterback Joe Burrow injured.

Injuries: Lions | Bengals

Fantasy nugget: Lions QB Jared Goff has averaged just 14.1 fantasy points per game on the road since 2021. Detroit would be wise to lean heavily on Jahmyr Gibbs, Montgomery and the running game. This matchup also has one of the higher totals on the slate, and the Bengals’ defense has given up the second-most fantasy points per game to running backs. See Week 5 rankings. — Moody

Betting nugget: The Lions are 11-2 ATS as road favorites since 2023. Read more. — ESPN Research

Maldonado’s pick: Lions 37, Bengals 34
Moody’s pick: Lions 33 Bengals 17
Walder’s pick: Lions 31, Bengals 26
FPI prediction: DET, 76.9% (by an average of 11.0 points)

Matchup must-reads: Lions put CB Reed on IR due to hamstring … QB Browning has Taylor’s ‘unwavering’ confidence … St. Brown-Goff connection shines again in 2 TD day vs. Browns

8:20 p.m. ET | NBC | Matchup rating: 64.4/100
ESPN BET: BUF -7.5 (49.5 O/U)

What we’re hearing on the Patriots: An unexpected injury issue popped up with one of the Patriots’ best players, as starting DT Milton Williams was added to the injury report Wednesday as a limited participant because of his ankle. Then Williams didn’t practice Thursday. He has played 72% of the defensive snaps through four games, has two sacks and has consistently created interior pressure. If he doesn’t play, that could thrust Khyiris Tonga into a starting role next to Christian Barmore. — Mike Reiss

What we’re hearing on the Bills: How will the rushing offense, which has been key to start the season, respond to the challenge the Patriots’ defense presents? RB James Cook has led Buffalo on the ground and has 100-plus yards in three straight games. New England, however, is tied for second in opponent rushing yards per game (77.5) and yards per rush (3.3). “[Cook] has such a really good understanding of what we’re trying to do, and how the guys are blocking and reading it. And he’s really special right now,” offensive coordinator Joe Brady said. — Alaina Getzenberg

Stat to know: Bills QB Josh Allen has 45 career games with both a passing touchdown and a rushing touchdown, tied with Cam Newton for the most by any player in NFL history. — ESPN Research

Bold prediction: Patriots rookie RB TreVeyon Henderson will record 64 or more rushing yards, doubling his current career high. Bills opponents have recorded a minus-14% pass rate over expectation this season, by far the lowest in the league. The Bills’ defense induces opponents’ runs. — Walder

Injuries: Patriots | Bills

Fantasy nugget: Bills TE Dalton Kincaid continues to split snaps and routes with others in the position group. You want to prioritize him in favorable matchups, like this week’s, which features one of the highest point totals on the slate. Kincaid catches passes from Allen in a Bills offense that ranks second in total yards per game. He faces a defense that gives up the ninth-most fantasy points per game to tight ends. See Week 5 rankings. — Moody

Betting nugget: The Patriots have covered four straight meetings with two outright wins as underdogs. Read more. — ESPN Research

Maldonado’s pick: Bills 38, Patriots 24
Moody’s pick: Bills 34, Patriots 24
Walder’s pick: Bills 31, Patriots 27
FPI prediction: BUF, 67.5% (by an average of 7.2 points)

Matchup must-reads: Diggs’ comeback is underway with the Patriots … Will Bosa’s final(?) chapter end with a happy ending in Buffalo?

Monday, 8:15 p.m. ET | ESPN | Matchup rating: 68.5/100
ESPN BET: KC -3.5 (46.5 O/U)

What we’re hearing on the Chiefs: The Chiefs know that Jaguars star Travis Etienne Jr. will be the best RB they’ve faced so far this season — and that list already includes Baltimore’s Derrick Henry and Philadelphia’s Saquon Barkley. Etienne has powered the Jaguars’ offense with 394 rushing yards, the third most in the league. “What’s stuck out to me watching film the past few days is how well he is on the edge,” LB Leo Chenal said of Etienne. “His stiff-arm is good, but it’s not just setting an edge. You have to have great eyes and continue to press the edge because he’ll bounce it out even if you’ve got a [defensive end] setting the edge two yards up the field. You better be ready to knock down a stiff-arm.” — Nate Taylor

What we’re hearing on the Jaguars: One of the things being stressed to the defensive players this week: Don’t get discouraged. QB Patrick Mahomes is an escape artist who can turn a bad play into a huge gain with an off-schedule throw from a weird arm angle. It’s going to happen at least once, but the key is to forget about it immediately when it does. “We’ve just got to go and huddle up, call the next play, refocus and understand that they’ve got good players, too, and they’re going to make some [big plays],” coach Liam Coen said. — Michael DiRocco

Stat to know: The Jaguars enter Week 5 leading the NFL in drops this season (10) and are the only team with a double-digit drop total. — ESPN Research

Bold prediction: Jaguars slot CB Jourdan Lewis will not allow a single reception to Chiefs WRs Hollywood Brown or JuJu Smith-Schuster while covering them. Lewis has allowed 0.7 yards per coverage snap this season (fifth best among slot corners with at least 80 coverage snaps) along with a minus-17% completion percentage over expectation, per NFL Next Gen Stats. — Walder

play

1:35

Why Worthy wants same chemistry with Mahomes as Kelce

Xavier Worthy joins “The Rich Eisen Show” to share his favorite Patrick Mahomes moment and reflects on why playing with him is a blessing.

Injuries: Chiefs | Jaguars

Fantasy nugget: The Chiefs’ defensive front ranks 31st in run stop win rate (25.5%), while the Jaguars’ offensive line ranks second in run block win rate (76.5%). This is an advantage Jacksonville must exploit, and with Etienne, it should be able to do so. He has had 16-plus touches in every game this season, and 17-plus fantasy points in three of them. See Week 5 rankings. — Moody

Betting nugget: The Chiefs are 4-1 ATS in their past five games as favorites. Read more. — ESPN Research

Maldonado’s pick: Chiefs 24, Jaguars 21
Moody’s pick: Chiefs 23, Jaguars 22
Walder’s pick: Chiefs 24, Jaguars 21
FPI prediction: KC, 62.8% (by an average of 5.1 points)

Matchup must-reads: WR Worthy unlocks Chiefs’ offense in return from shoulder injury … Coen has revived the Jaguars’ run game … Jaguars’ Walker has wrist surgery, could play vs. Chiefs

Source link

Sep 26, 2025, 06:00 AM ET

The Week 4 NFL schedule for the 2025 season brings some exciting matchups.

Rookie QB Jaxson Dart will make his debut against the surging Chargers. Packers edge rusher Micah Parsons makes his highly anticipated return to Dallas. And the Ravens and Chiefs — two of the league’s most unlikely 1-2 teams — will face off in an AFC showdown.

We have you covered with everything you need to know. Our NFL Nation reporters take you inside the locker room with the best thing they heard this week, and ESPN Research provides a key stat to know and a betting nugget for each contest. Plus, analytics writer Seth Walder makes a bold prediction for each matchup, and fantasy analyst Eric Moody shares fantasy football intel. We also have Football Power Index (FPI) matchup quality ratings (out of 100) and game projections, and three analysts — Pamela Maldonado, Moody and Walder — give us final score picks for every game.

Let’s get into the full Week 4 slate, which culminates with two “Monday Night Football” matchups — one between the Jets and Dolphins on ESPN, and one between the Bengals and Broncos. (Game times are Sunday unless otherwise noted.)

Jump to a matchup:
PIT-MIN | PHI-TB | CLE-DET
LAC-NYG | NO-BUF | WSH-ATL
CAR-NE | TEN-HOU | IND-LAR
JAX-SF | BAL-KC | CHI-LV
GB-DAL | NYJ-MIA | CIN-DEN

Thursday: SEA-ARI

9:30 a.m. ET | NFL Network | Matchup rating: 48.6/100
ESPN BET: MIN -2.5 (40.5 O/U)

What we’re hearing on the Steelers: Pittsburgh’s defense has allowed a league-high 32 plays of at least 20 passing yards or 12 rushing yards this season. The Vikings enter Sunday’s matchup with just eight plays of 20 yards or more, but they return a major target in WR Jordan Addison, who served a three-game suspension. Pittsburgh, though, could also get help in the secondary with the potential return of S DeShon Elliott (knee) and CB Joey Porter Jr. (hamstring), who both haven’t played since Week 1. — Brooke Pryor

What we’re hearing on the Vikings: The Vikings had a chance to sign QB Aaron Rodgers, who instead joined the Steelers after the Vikings committed to giving J.J. McCarthy first-team snaps throughout the spring and summer. McCarthy will miss his second consecutive game because of a sprained ankle, and Carson Wentz will start. The question the Vikings asked themselves this offseason was if they would be better with McCarthy on a rookie contract and a backup like Wentz, whose cap number is $1.2 million this season, or Rodgers at $14.2 million. Sunday’s game will be a litmus test for that question. — Kevin Seifert

Stat to know: The Vikings have allowed an average of 141.3 passing yards per game, which is the third fewest in the league. On the other hand, the Steelers are 24th in the NFL in passing yards per game (184.0). — ESPN Research

Bold prediction: Vikings LB Andrew Van Ginkel will record a pick-six. How could I not pick this? Van Ginkel is the king of jumping horizontal passes and taking them to the house, and no one loves a screen pass more than Steelers offensive coordinator Arthur Smith. It’s a match made in defensive touchdown paradise. — Walder

Injuries: Steelers | Vikings

Editor’s Picks

2 Related

Fantasy nugget: Vikings TE T.J. Hockenson struggled early in the season but exploded in Week 3 with 15.9 fantasy points. He tied for the team lead in receptions (five) and finished second in targets (six) and yards (49). Despite splitting time with Josh Oliver and Ben Yurosek, Hockenson has played more snaps and routes, keeping him a fantasy starter, especially with a favorable matchup against a Pittsburgh defense that gives up the second-most points to tight ends. See Week 4 rankings. — Moody

Betting nugget: The Steelers are 20-8-2 ATS (against the spread) as home underdogs (18-12 outright) under coach Mike Tomlin. Read more. — ESPN Research

Maldonado’s pick: Vikings 24, Steelers 18
Moody’s pick: Vikings 24, Steelers 20
Walder’s pick: Vikings 27, Steelers 19
FPI prediction: MIN, 57.8 (by an average of 3.1 points)

Matchup must-reads: Peppers leads defensive surge for Steelers, but there’s room for improvement … Why Vikings wanted to play back-to-back in Dublin, London … … Will Vikings’ McCarthy start over Wentz once healthy?

1 p.m. ET | Fox | Matchup rating: 73.9/100
ESPN BET: PHI -3.5 (43.5 O/U)

What we’re hearing on the Eagles: The Eagles are 1-3 in Tampa Bay under coach Nick Sirianni and have not been their best in the Florida heat. They flew out Friday, a day early, to get acclimated to the weather (it’s supposed to be 90 degrees with 68% humidity on Sunday). But not everyone is convinced the approach will pay dividends. “You don’t practice in heat one day and say you’re acclimated or take a pill and say you’re acclimated,” defensive coordinator Vic Fangio said. “The key will be, I mean, it’s a mindset, No. 1. No. 2, we need to not let them have eight-, 10-, 12-play drives on us.” — Tim McManus

What we’re hearing on the Buccaneers: Bucs coach Todd Bowles was asked about being a “hero” to the people of Philadelphia because he has come out in support of the tush push. The Elizabeth, New Jersey, native and Temple grad who spent one season as an assistant in Philly joked, “I think the only place I might be a hero at is Ishkabibble’s down on South Street, getting the cheesesteak. Other than that … It’s a good play, it’s a creative play for them, and we’ve got to get better as defensive coaches trying to be creative to stop it.” — Jenna Laine

Stat to know: Eagles QB Jalen Hurts is 1-4 in his career against Buccaneers (including the playoffs), his most losses versus any team. — ESPN Research

Bold prediction: Philadelphia will record a positive pass rate over expectation (per NFL Next Gen Stats) for the first time this season. Tampa Bay ranks first in EPA allowed per opponent designed run, so the Eagles are going to have to rely on Hurts’ dropbacks, perhaps even more than they did last week. The good news for the Eagles: They can win that way, too. — Walder

Injuries: Eagles | Buccaneers

play

0:55

Stephen A.: Mayfield and Tampa Bay are legit threats

Stephen A. Smith details why the Buccaneers shouldn’t be ignored with Baker Mayfield at quarterback.

Fantasy nugget: Emeka Egbuka takes over as the Buccaneers’ No. 1 WR with Mike Evans sidelined for multiple weeks (hamstring). He has racked up 21 targets and 51 fantasy points through three games and will be busy against the Eagles’ secondary. See Week 4 rankings. — Moody

Betting nugget: The Buccaneers are 15-6 ATS as underdogs (10-11 outright) since acquiring QB Baker Mayfield in 2023, the best record in the NFL in that span. Read more. — ESPN Research

Maldonado’s pick: Eagles 34, Buccaneers 27
Moody’s pick: Eagles 24, Buccaneers 23
Walder’s pick: Eagles 24, Buccaneers 17
FPI prediction: PHI, 54.6% (by an average of 1.8 points)

Matchup must-reads: Inside the tactic NFL teams are using to combat the tush push … Buccaneers’ Evans expected to miss 3-4 weeks, sources say

1 p.m. ET | Fox | Matchup rating: 57.5/100
ESPN BET: DET -9.5 (44.5 O/U)

What we’re hearing on the Browns: Cleveland’s defense has a claim as the league’s best, allowing the fewest yards in the NFL per game (204.3). However, the Lions’ offense, which ranks second in scoring and first in EPA per play, will be Cleveland’s biggest test to date. The Browns will be on alert for everything, from Detroit’s use of motion and trick plays to its fourth-down aggressiveness. “Runs, play-action, screens, they’re probably the leader in the NFL when it comes to combining all three of those things on first and second down,” defensive coordinator Jim Schwartz said. “We’ll have to take away what they do best. Every play is going to be a battle.” — Daniel Oyefusi

What we’re hearing on the Lions: After their first win at Baltimore as an organization, the Lions are looking to avoid a trap game against the Browns. Detroit has a league-leading 11 red zone touchdowns this season, while its defense sacked Ravens QB Lamar Jackson seven times. The Lions hope to continue that output on Sunday. “I can understand emotions being high … but ultimately every game in the NFL takes a certain amount of focus and a certain amount of drive and willingness,” edge rusher Aidan Hutchinson said. “And it’s like if you don’t show up, you’re going to get your butt kicked, and we all know that.” — Eric Woodyard

Stat to know: Lions WR Amon-Ra St. Brown has 450 receptions in 69 games since entering league in 2021 (most in the NFL over span). Since the AFL/NFL merger in 1970, only two players have more receptions in their first 70 career games: Michael Thomas with 510 (2016-20) and Justin Jefferson with 451 (2020-24). — ESPN Research

Bold prediction: The Browns will hold both Jahmyr Gibbs and David Montgomery to under 4.0 yards per carry. Cleveland’s defense ranks first in yards allowed per rush (2.3) and run stop win rate (38%). — Walder

Injuries: Browns | Lions

All of ESPN. All in one place.

Watch your favorite events in the newly enhanced ESPN App. Learn more about what plan is right for you. Sign Up Now

Fantasy nugget: The Browns’ defensive front is not to be trifled with and currently leads the league in run stop win rate. The Lions had a ton of success running the ball in Week 3 with Gibbs and Montgomery. However, Detroit would be wise to lean on QB Jared Goff, St. Brown and the passing game against the Browns. See Week 4 rankings. — Moody

Betting nugget: The Lions are 12-4 ATS in September under coach Dan Campbell. Read more. — ESPN Research

Maldonado’s pick: Lions 38, Browns 7
Moody’s pick: Lions 30, Browns 16
Walder’s pick: Lions 24, Browns 13
FPI prediction: DET, 78.1% (by an average of 12.0 points)

Matchup must-reads: How the Browns’ defense has turned back the clock to 2023 form … Rushing attack, pass rush help Lions defeat Ravens on road … Deion thinks Shedeur will start for Browns in ’25 … GM Holmes wants to build a dynasty — and a legacy — in Detroit

1 p.m. ET | CBS | Matchup rating: 51.6/100
ESPN BET: LAC -6.5 (43.5 O/U)

What we’re hearing on the Chargers: Chargers LB Daiyan Henley said the defense is taking Sunday’s matchup against rookie QB Jaxson Dart as a “challenge.” “This is going to be a guy that’s trying to prove something. And so, for us, we have to also prove how tough of a defense we are to face,” Henley said. “So, for us, he’s going to get our best, and I’m sure we’re going to get his.” The Chargers are currently allowing the ninth-lowest passing yards per game on defense (182.0). — Kris Rhim

What we’re hearing on the Giants: The Giants made the QB switch from Russell Wilson to Dart this week, even though they’re set to face a tough Chargers defense. But the hope is that the rookie adds some new elements to the offense and finally gets the team in the win column. “I think the biggest thing for me is I want to do my best to be a spark,” Dart said. “I want to create excitement on the field. I want to be explosive when opportunities are there. Try to just bring a little bit of swagger.” — Jordan Raanan

Stat to know: Quarterbacks making their first career start against the Chargers are 3-17 in the Super Bowl era (since 1967), but 2-2 in such games since 2019. — ESPN Research

Bold prediction: Chargers CB Donte Jackson will record an interception. Jackson has the lowest yards allowed per coverage snap (0.2) among all outside corners with at least 75 coverage snaps this season, per NFL Next Gen Stats, and is doing it without a low target rate (13%). Facing Dart in his debut, the chances of a pick are higher. — Walder

Injuries: Chargers | Giants

play

1:20

Why there’s a ‘ton of pressure’ on Jaxson Dart to win

Dan Orlovsky breaks down what’s at stake for Jaxson Dart and Brian Daboll at the New York Giants.

Fantasy nugget: Chargers RB Omarion Hampton is set up for significant touches in the backfield with Najee Harris out for the season after suffering an Achilles injury in Week 3. Hampton finished with 25 touches and 24.9 fantasy points last week and could replicate that production against a Giants defense that has allowed the fourth-most fantasy points per game to running backs. See Week 4 rankings. — Moody

Betting nugget: The Giants are 3-11 ATS in their past 14 games as underdogs. Read more. — ESPN Research

Maldonado’s pick: Chargers 30, Giants 17
Moody’s pick: Chargers 33, Giants 23
Walder’s pick: Chargers 27, Giants 20
FPI prediction: LAC, 76.0% (by an average of 10.6 points)

Matchup must-reads: How RB Harris’ Achilles injury affects the Chargers … No turning back now, Giants all-in on Dart as QB starter

1 p.m. ET | CBS | Matchup rating: 50.7/100
ESPN BET: BUF -15.5 (47.5 O/U)

What we’re hearing on the Saints: Saints coach Kellen Moore expressed his confidence in starting QB Spencer Rattler following the loss to the Seahawks. Moore indicated the Saints wouldn’t be following the Giants’ lead and switching quarterbacks anytime soon, and said Rattler realizes how much confidence the team has in him. He thinks Rattler — who is 0-9 as a starter dating back to last season — is headed in the right direction. “It’s frustrating because Spencer hasn’t been able to get a win in this league, and he’s earned it and he deserves it. He’s done so much good,” Moore said. — Katherine Terrell

What we’re hearing on the Bills: Despite sitting on the largest point spread of the season, per ESPN BET, the emphasis from the Bills is that they are treating Sunday’s game like any other. QB Josh Allen said he expects the Saints “to have their ears pinned back. They want to win as badly as anybody in the league right now. And again, there’s no easy games in this league.” The Bills have a 13-game home winning streak in the regular season but could be without three starters (DT Ed Oliver, LB Matt Milano and RT Spencer Brown) due to injuries. — Alaina Getzenberg

Stat to know: The Bills have gone eight straight games without a turnover (including the playoffs), which is tied with the 2024 Chiefs for the longest streak with zero turnovers since 1933. — ESPN Research

Bold prediction: Saints LB Demario Davis will lead the NFL in combined tackles in Week 4. The Bills will get out to a lead so large that they will run the ball a ton. And Davis ranks second among linebackers in tackle rate versus run plays, earning a tackle or assist on 29% of opponent’s runs. — Walder

Injuries: Saints | Bills

Fantasy nugget: The Bills are heavy home favorites against the Saints, which bodes well for RB James Cook. He has had 18-plus touches and 20-plus fantasy points in three straight games. Buffalo’s offensive line, the league leader in run block win rate (76.6%), should dominate a Saints front that has allowed the seventh-most fantasy points per game to running backs. In deeper formats, don’t overlook fellow RB Ty Johnson as a potential sleeper. See Week 4 rankings. — Moody

Betting nugget: Rattler is 1-8 ATS in his career as a starter. Read more. — ESPN Research

Maldonado’s pick: Bills 35, Saints 14
Moody’s pick: Bills 34, Saints 16
Walder’s pick: Bills 33, Saints 7
FPI prediction: BUF, 80.5% (by an average of 13.1 points)

Matchup must-reads: Davis and Jordan’s leadership is pivotal for 0-3 Saints … Lingering Bills questions amid historic run on turnover margin … Winless Saints lament Week 3 loss: ‘A very powerful lesson for our guys on adversity’

1 p.m. ET | CBS | Matchup rating: 49.6/100
ESPN BET: WSH -1.5 (44.5 O/U)

What we’re hearing on the Commanders: With a banged-up offense missing multiple starters — perhaps as many as five on Sunday — Washington’s defense needs to take the lead. And that means stopping Falcons RB Bijan Robinson at all costs. Washington ranks 12th in rushing yards allowed per game (100.7) and eighth in yards per carry (3.7) after investing in bigger linemen and more depth up front. But stopping Robinson will prove challenging. “I see no weaknesses for the guy,” defensive coordinator Joe Whitt Jr. said. “He can do it all — run inside, outside, can catch. He does it all very, very well.” — John Keim

What we’re hearing on the Falcons: Is this a must-win game for the Falcons? Maybe not since it’s only Week 4, but it is a must-look-competent game for them. Specifically, their offense needs to step up after last week’s 30-0 drubbing at the hands of the Panthers. Coach Raheem Morris is not too worried about Atlanta showing up this week. He said that due to “human nature,” there’s more urgency after any loss and “particularly a loss like that.” — Marc Raimondi

Stat to know: Commanders QB Marcus Mariota made 13 starts for the Falcons in 2022, going 5-8 with 15 passing touchdowns and nine interceptions. He was replaced by then-rookie Desmond Ridder for the final four games of the season. — ESPN Research

Bold prediction: Falcons QB Michael Penix Jr. will average under 6.0 air yards per attempt. After last week’s disastrous performance, watch to see if the Falcons — and Penix — err on the side of caution as they try to get back on track. — Walder

Injuries: Commanders | Falcons

play

1:45

Should the Rams be encouraged despite loss to Eagles?

Rex Ryan explains why the Rams proved they are among the best teams in the NFL even with a loss to the Eagles.

Fantasy nugget: This could be the week WR Drake London breaks out. The Commanders’ defensive front ranks third in run stop win rate (35.4%) and has done a great job limiting fantasy points to running backs. But Washington has allowed big plays through the air. The Falcons fired WR coach Ike Hilliard after offensive struggles, and Penix hasn’t thrown a touchdown to a wide receiver or tight end yet this season. But Week 4 could be London’s moment. See Week 4 rankings. — Moody

Betting nugget: The Commanders have covered all four meetings with the Falcons since 2021. Read more. — ESPN Research

Maldonado’s pick: Falcons 29, Commanders 27
Moody’s pick: Commanders 23, Falcons 17
Walder’s pick: Commanders 20, Falcons 17
FPI prediction: WSH, 58.6% (by an average of 3.9 points)

Matchup must-reads: Commanders’ Daniels (knee) practices, says status up to doctors … Dazed Falcons look to put 30-0 loss to Panthers behind them … Source: Commanders’ McLaurin seeks more input on quad injury

1 p.m. ET | Fox | Matchup rating: 30.2/100
ESPN BET: NE -5.5 (42.5 O/U)

What we’re hearing on the Panthers: Panthers TE Tommy Tremble referred to the height rookie WR Tetairoa McMillan reached for a 4-yard catch from QB Bryce Young against Atlanta as “Mario jumping,” to which McMillan insisted this isn’t Mario ball. Sunday’s game won’t be either. It’ll be won in the trenches, where it’ll be strength against strength, as Carolina will want to a run against a New England defense that’s allowing only 60.3 rushing yards per game. — David Newton

What we’re hearing on the Patriots: Patriots coach Mike Vrabel said he spent two hours Tuesday night studying the Panthers’ kickoff coverage, which includes knuckleball kicks from Ryan Fitzgerald. They’ve proved challenging for opposing returners to handle. “It’s impressive. He kicks a good kick, [a] dirty kick. He’s had the returners sometimes confused,” said Vrabel, who believes Patriots returners TreVeyon Henderson and Antonio Gibson have the skill set to decide games. But the New England kick return unit was outplayed in its Week 3 loss. — Mike Reiss

Stat to know: Young is 1-14 in his first 15 career road starts, tied with Steve DeBerg, Dan Pastorini and Blake Bortles for the second-worst record by a QB through his first 15 road starts since starts were first tracked in 1950. — ESPN Research

Bold prediction: Patriots QB Drake Maye will throw for 300 or more yards for the first time in his career. No team has a larger difference between its EPA per dropback and EPA per designed carry in favor of the passing game than New England. So why not let Maye air it out all day? — Walder

Injuries: Panthers | Patriots

Breaking News from Adam Schefter

Download the ESPN app and enable Adam Schefter’s news alerts to receive push notifications for the latest updates first. Opt in by tapping the alerts bell in the top right corner. For more information, click here.

Fantasy nugget: TE Hunter Henry has emerged as Maye’s top target in New England, coming off a 29-point fantasy performance in Week 3. He has seen eight-plus targets in two of three games, and now faces a Panthers defense allowing the eighth-most fantasy points to tight ends. See Week 4 rankings. — Moody

Betting nugget: This is the largest the Patriots have been a favorite since Week 7 of 2022, when they were favored by 8.5 versus the Bears. They lost that game 33-14. Read more. — ESPN Research

Maldonado’s pick: Panthers 20, Patriots 15
Moody’s pick: Patriots 24, Panthers 20
Walder’s pick: Patriots 30, Panthers 17
FPI prediction: NE, 56.1% (by an average of 2.4 points)

Matchup must-reads: Kuechly sees potential in Panthers’ defensive youth … Patriots’ Vrabel on Stevenson’s costly fumbles, benching: Still ‘need him’ … Panthers’ defense comes alive in 30-0 shutout of Falcons

1 p.m. ET | CBS | Matchup rating: 22.6/100
ESPN BET: HOU -7.5 (38.5 O/U)

What we’re hearing on the Titans: The Texans’ defense is allowing 17.0 points per game, tied for the fifth-best average in the league. Houston’s pass rush has also generated nine sacks (tied for fourth best in the NFL), which presents a tough challenge for a Titans offense that has scored only 17.0 points per game and has allowed a league-worst 15 sacks. The Titans hope new playcaller Bo Hardegree can have an impact similar to when he took over as the interim offensive coordinator for the Raiders in 2023 and helped boost Las Vegas’ average points per game by seven. — Turron Davenport

What we’re hearing on the Texans: Expect some extra juice between Texans WR Nico Collins and Titans CB L’Jarius Sneed. Sneed, when asked about Collins earlier this week, said “who?” in a dismissive way. When Collins was asked about Sneed’s comments, he said “he knows who I am.” As the Texans try to get their last-ranked scoring offense going, expect Collins to do everything in his power to get the unit some juice. — DJ Bien-Aime

Stat to know: The Texans have yet to score 20 points in a game this season. The last time Houston scored less than 20 points in each of the first four games of a season was in 2002, the team’s debut season. — ESPN Research

Bold prediction: Titans WR Calvin Ridley will record an 80-plus-yard receiving game. Ridley has the third-worst receiving yards over expectation (minus-82) in the NFL this season, behind only Jaguars WR Brian Thomas Jr. and Panthers WR Xavier Legette. Which, granted, isn’t an amazing sign. But it is a sign that the ball is coming his way, and I expect that to continue. One of these days he’s going to have a big game. — Walder

Injuries: Titans | Texans

Fantasy nugget: The Texans’ offensive line has struggled mightily this season and currently ranks 21st in run block win rate (70.3%). The Titans’ defensive front has allowed the third-most fantasy points per game to running backs. RB Nick Chubb is on the flex radar, and for those in need of a sleeper, don’t overlook RB Woody Marks. See Week 4 rankings. — Moody

Betting nugget: Titans coach Brian Callahan is 3-17 ATS, the worst mark of any coach in the Super Bowl era. Read more. — ESPN Research

Maldonado’s pick: Texans 17, Titans 10
Moody’s pick: Texans 23, Titans 17
Walder’s pick: Texans 27, Titans 17
FPI prediction: HOU, 69.3% (by an average of 7.9 points)

Matchup must-reads: Why Titans coach Callahan gave up playcalling duties … Texans say being ‘close’ in one-score games not good enough … Callahan says Brownlee trade doesn’t signal Titans fire sale … Texans release Gardner-Johnson after just three games

4:05 p.m. ET | Fox | Matchup rating: 66.6/100
ESPN BET: LAR -3.5 (50.5 O/U)

What we’re hearing on the Colts: The Colts have enjoyed great rushing success so far, with star RB Jonathan Taylor leading the NFL with 338 yards. But the Rams offer a stiff test, having allowed just one rushing touchdown and 3.9 yards per rush. Whether Taylor and the Colts can achieve some rushing consistency will have an impact on how successful their surprisingly efficient passing game can remain. The Colts have achieved great offensive balance, but whether Taylor can find running lanes against a tough defensive front remains to be seen. — Stephen Holder

What we’re hearing on the Rams: The Rams have 12 sacks this season, which is tied with the Broncos for the most in the NFL. Colts QB Daniel Jones has been sacked only twice, which is the fewest among qualified quarterbacks, according to ESPN Research. Rams coach Sean McVay noted the efficiency the Colts have played with this season, saying, “They’re not playing behind the sticks.” “He’s obviously got the mobility to be able to make you pay as a runner, but I think he’s reading well with his feet,” McVay said of Jones. “He throws the ball with great accuracy and anticipation.” — Sarah Barshop

Stat to know: Rams QB Matthew Stafford co-leads the NFL in completions (29), passing touchdowns (four with zero interceptions) and first downs (17) on play-action this season. Meanwhile, Indianapolis’ defense has 10 interceptions on play-action throws under coach Shane Steichen (since 2023) — tied for second most over that span. — ESPN Research

Bold prediction: Taylor will run the ball more than 20 times in a loss by at least seven points. That would be the most by any player in such a loss this season. But expect the Colts to be run-heavy no matter what on Sunday: They already lean that way, and the Rams’ defense ranks sixth in EPA allowed per opponent dropback but 22nd against the run. — Walder

Injuries: Colts | Rams

play

2:13

Stephen A.: Travis Kelce knows he’s not what he used to be

Stephen A. Smith understands why Travis Kelce expressed his frustration in a heated sideline exchange with Andy Reid.

Fantasy nugget: Rams RB Kyren Williams is coming off a Week 3 game in which he set season highs in touches (22), total yards (112) and fantasy points (19.2). He faces a Colts defensive front ranked 27th in run stop win rate (26.8%). With the Rams’ offensive line — 11th in run block win rate (72.9%) — holding the advantage, McVay and Williams should be able to capitalize. See Week 4 rankings. — Moody

Betting nugget: The Colts are 3-0 ATS this season with the highest average cover margin in the NFL (13.8). Read more. — ESPN Research

Maldonado’s pick: Rams 31, Colts 27
Moody’s pick: Colts 28, Rams 24
Walder’s pick: Rams 24, Colts 16
FPI prediction: LAR, 55.5% (by an average of 2.5 points)

Matchup must-reads: Colts sign CB Hilton after Moore injured … Rams have to come back stronger after first loss of season

4:05 p.m. ET | Fox | Matchup rating: 58.7/100
ESPN BET: SF -3.5 (47.5 O/U)

What we’re hearing on the Jaguars: Drops have been the topic of the week. That’s understandable, as the Jaguars lead the league with 10 and are coming off a week in which they dropped six — including three by WR Brian Thomas Jr. Coach Liam Coen’s message to the pass catchers: “Attack the ball.” He wants them to catch the ball out in front of their bodies and not let it cross their eyes. Drops are one of the main reasons the passing offense hasn’t gotten into rhythm yet. — Michael DiRocco

What we’re hearing on the 49ers: The 49ers have spent the week trying to figure out how to cover for the loss of star DE Nick Bosa, who is out for the season with a torn ACL. “Losing Nick is a big deal,” LB Fred Warner said. “That’s one of the best players, not just on our team but on the planet. We’ve got to find ways to continue to create those pressures.” One possibility? An increased blitz rate. In the 97 games the Niners have played with Bosa, they’ve blitzed just 20% of the time. In the 18 games they’ve played without him, that number has spiked to 31.9%. That could help against Jacksonville and QB Trevor Lawrence, who has thrown 13 interceptions when blitzed since 2021, tied for third most among qualified quarterbacks in that span. — Nick Wagoner

Stat to know: Niners RB Christian McCaffrey has had 50 rushing yards and 50 receiving yards in each game this season. He is seeking to become the second player in NFL history to start a season with four such consecutive games. — ESPN Research

Bold prediction: The 49ers will not sack Lawrence. The 49ers’ pass rush takes a big hit without Bosa, and Lawrence has been sacked on only 2.5% of dropbacks this season — the second-lowest rate among quarterbacks. — Walder

Injuries: Jaguars | 49ers

Weekly NFL game expert picks

• Game picks from our NFL experts »
• Betting notes » | More NFL coverage »

Fantasy nugget: The 49ers’ offense has been hit hard by injuries to QB Brock Purdy (toe), TE George Kittle (hamstring) and WR Jauan Jennings (shoulder, ankle) — and WR Ricky Pearsall has taken advantage. He has scored 14-plus fantasy points in two of three games, including a season-high 19.7 in Week 3. Next up is a Jaguars defense allowing the third-most receptions and sixth-most fantasy points per game to WRs. See Week 4 rankings. — Moody

Betting nugget: The Jaguars have lost seven straight games following a win (2-5 ATS). Read more. — ESPN Research

Maldonado’s pick: 49ers 20, Jaguars 10
Moody’s pick: 49ers 28, Jaguars 21
Walder’s pick: 49ers 23, Jaguars 17
FPI prediction: SF, 51.4% (by an average of 0.4 points)

Matchup must-reads: Jaguars QB Lawrence showing progress despite drops, impatient throws … Losing Bosa is ‘a big deal’: Here’s how the 49ers will look to replace him … Jaguars defense has found success forcing turnovers … Five things we’ve learned about 49ers QB Jones in 2025

4:25 p.m. ET | CBS | Matchup rating: 86.8/100
ESPN BET: BAL -2.5 (48.5 O/U)

What we’re hearing on the Ravens: The Ravens’ defense, which ranks last in the NFL for the first time since 2021, now faces its most challenging quarterback. The Ravens are 1-5 versus Patrick Mahomes (including the playoffs), who has thrown 14 touchdowns and three interceptions against the Baltimore defense. “I think one thing we touched on was just staying on your feet when he pump-fakes,” OLB Odafe Oweh said. “And then when you get there, try to hit him legally, as legally as you can in today’s NFL. We have to respect his playmaking ability.” — Jamison Hensley

What we’re hearing on the Chiefs: Following their first victory, the Chiefs are looking to have a complete performance on offense against the Ravens, hoping to build off the strong second half they had against the Giants. The expected return of speedy WR Xavier Worthy should help, too. “It’s going to make us even better because guys had to step up and they have,” Mahomes said. “You’ve seen Hollywood [Brown], you’ve seen JuJu [Smith-Schuster] and you’ve seen Tyquan [Thornton] all step up into their roles. We’ll continue to get better and better as the season goes, but it’ll be an important week this week.” — Nate Taylor

Stat to know: The Ravens have scored 111 points this season, which is the most by a team with a losing record through three games in NFL history. The most points by a team with a losing record through four games is 140 by the 2022 Lions, who finished the season 8-9 and missed playoffs. — ESPN Research

Bold prediction: The Ravens will win by double digits. Detroit was able to run the ball incredibly effectively against the Ravens last week, and that gave it an edge. The Chiefs have no such threat, and without it, I think we’ll see Baltimore as the clearly superior team over Kansas City. — Walder

Injuries: Ravens | Chiefs

play

1:46

Mike McCarthy breaks down Cowboys’ defensive struggles

Mike McCarthy joins “The Pat McAfee Show” to discuss whether the Cowboys can make defensive improvements before their Week 4 matchup vs. the Packers.

Fantasy nugget: Chiefs TE Travis Kelce hasn’t been the fantasy cheat code we’re used to in recent seasons. But with Kansas City’s offense struggling, it’ll need him heavily involved. Baltimore has allowed the seventh-most fantasy points per game to tight ends. Kelce has averaged 7.1 targets, six catches and 78.2 yards per game against Baltimore in his career. See Week 4 rankings. — Moody

Betting nugget: Ravens QB Lamar Jackson is 31-15-2 ATS on the road. Read more. — ESPN Research

Maldonado’s pick: Ravens 21, Chiefs 20
Moody’s pick: Ravens 31, Chiefs 26
Walder’s pick: Ravens 31, Chiefs 20
FPI prediction: BAL, 50.3% (by an average of 0.5 points)

Matchup must-reads: Ravens’ Humphrey: Struggling defense can’t put unfair expectations on Jackson … Thornton finding chemistry with Mahomes … Chiefs’ Reid brushes off Kelce dustup on sideline

4:25 p.m. ET | CBS | Matchup rating: 38.7/100
ESPN BET: CHI -1.5 (47.5 O/U)

What we’re hearing on the Bears: Coach Ben Johnson tried to recognize QB Caleb Williams for being named NFC Offensive Player of the Week, but the quarterback wasn’t having it. Williams had quickly turned his focus from the Bears’ first win of the season to the Raiders and the things he can carry over from his second-ever game with four touchdowns. “He knows he needs to have an even better performance here this week to give us the best chance to win,” Johnson said. Chicago’s offensive output is significantly less on the road (15.9 PPG, 1-8 with Williams at QB), but the way Williams is playing (18 TDs, 2 INTs over his past 14 starts) has him vying for the second road victory of his career. — Courtney Cronin

What we’re hearing on the Raiders: Could rookie RB Ashton Jeanty’s breakout game come against the Bears? The opportunity is there: Chicago enters Sunday’s matchup allowing 5.5 rushing yards per carry (31st in the league). Jeanty, on the other hand, has averaged 3.1 yards per carry through three games. Even though he has flashed the skill set that made him worthy of being a top-10 pick, he hasn’t impacted the run game as expected. “I think he’s right where he needs to be,” QB Geno Smith said. “We have to help him … because when he gets an open field, man, he’s hard to stop. So, we’ve just got to get him into some more space and allow him to do his thing.” — Ryan McFadden

Stat to know: Last week was the first game of Williams’ career where he was not sacked. Chicago is now seeking have consecutive games without allowing a sack for the first time since November 2005. — ESPN Research

Bold prediction: Raiders TE Brock Bowers will bounce back with a 90-plus-yard receiving game. Of all targets against the Bears, 27% have gone to tight ends, the highest rate in the league. — Walder

Injuries: Bears | Raiders

Best of NFL Nation

• Is the Seahawks’ new offense working?
• Which 0-3 team needs a win most?
• Cards’ Kyler Murray making key adjustments
• What will Parsons’ return to Dallas be like?
• Winless Saints lean on Davis, Jordan’s leadership

Fantasy nugget: Raiders WR Jakobi Meyers is coming off a quiet Week 3, but don’t overreact. He saw 10-plus targets and scored 12-plus fantasy points in each of the first two games this season. The Bears have allowed the fourth-most fantasy points per game to wide receivers and are particularly vulnerable to slot production, where Meyers runs most of his routes. See Week 4 rankings. — Moody

Betting nugget: The Bears are 12-23 ATS on the road since 2021. Read more. — ESPN Research

Maldonado’s pick: Bears 34, Raiders 24
Moody’s pick: Bears 21, Raiders 20
Walder’s pick: Bears 34, Raiders 31
FPI prediction: CHI, 50.9% (by an average of 0.5 points)

Matchup must-reads: No sacks? New look of success for Williams, Bears … Will Raiders’ Carroll consider changes after another rough loss?

8:20 p.m. ET | NBC | Matchup rating: 64.3/100
ESPN BET: GB -6.5 (47.5 O/U)

What we’re hearing on the Packers: The Packers have had all kinds of injury issues on the offensive line. They finished last week’s loss without RT Zach Tom (oblique) and LG Aaron Banks (groin), and the Browns pressured QB Jordan Love at a 42% rate — the highest of his career — and made it impossible for RB Josh Jacobs to run (16 carries, 30 yards). Green Bay could be without both linemen again on Sunday. But Elgton Jenkins, the Pro Bowl guard who moved to center this offseason, believes he could have helped had he played better. “I feel like I’ve played like s—, honestly,” Jenkins said. “Like, I can play a lot better. A lot of things, a lot of small detail things that I can fix, overall. But I just feel like I’ve played like s— and definitely got to play better moving forward.” — Rob Demovsky

What we’re hearing on the Cowboys: Maybe you’ve heard that edge Micah Parsons is returning to AT&T Stadium with the Packers this week. But inside the Cowboys’ locker room, it’s not a topic the players discuss unless asked about it by the media. “We love Micah,” DT Solomon Thomas said. “He was a brother here of ours. And we wish him the best, and so happy for him that he got record-breaking money, and he deserves all that money. But as a team, we’re not even thinking about that. We’re thinking about Green Bay, getting better from Chicago, fixing those mistakes. And on Sunday, it’s another championship opportunity to be our best. That all we’re focused on.” — Todd Archer

Stat to know: Parsons makes his return to Dallas as a league coleader with 14 QB pressures this season (tied with the Bills’ Joey Bosa and the Broncos’ Nik Bonitto), and as the sole leader in pass rush wins with 17. — ESPN Research

Bold prediction: Packers WRs Romeo Doubs and Matthew Golden will both record at least 65 receiving yards. Among outside cornerbacks with at least 75 coverage snaps, Cowboys CBs Kaiir Elam (2.3) and Trevon Diggs (1.7) rank second- and fourth-worst in yards allowed per coverage snap, respectively, per NFL Next Gen Stats. — Walder

Injuries: Packers | Cowboys

Fantasy nugget: Cowboys TE Jake Ferguson has seen 12-plus targets and scored 16-plus fantasy points in back-to-back games. With WR CeeDee Lamb sidelined by an ankle injury, Ferguson should remain a focal point of the Cowboys’ offense. The Packers’ defense is tough, but it has allowed the sixth-most fantasy points per game to tight ends this season. See Week 4 rankings. — Moody

Betting nugget: The Packers are 61-42 ATS under coach Matt LaFleur, but only 11-16 ATS as road favorites, including a loss last week as 7.5-point road favorites against the Browns. Read more. — ESPN Research

Maldonado’s pick: Packers 34, Cowboys 17
Moody’s pick: Packers 31, Cowboys 24
Walder’s pick: Packers 27, Cowboys 24
FPI prediction: GB, 60.0% (by an average of 3.6 points)

Matchup must-reads: Parsons’ hobby? Beating Packers teammates at H-O-R-S-E, pingpong and bowling … What’ll it be like for Parsons at Cowboys? … Parsons not upset Cowboys won’t recognize his return … Why Cowboys’ Jones likes talking contracts with players

Monday, 7:15 p.m. ET | ESPN | Matchup rating: 22.0/100
ESPN BET: MIA, -2.5 (45.5 O/U)

What we’re hearing on the Jets: It seems likely QB Justin Fields (concussion) will return to the lineup soon. If he does return for Week 4, Fields will need the support of a strong rushing attack — something the Jets haven’t had since Week 1. RB Breece Hall has struggled in the past two games (2.6 yards per carry), so don’t be surprised if Braelon Allen (5.1) sees an increased role. Coach Aaron Glenn noted that reestablishing the ground game is imperative. — Rich Cimini

What we’re hearing on the Dolphins: Dolphins TE Darren Waller (hip) has practiced all week and is expected to make his season debut Monday. His coaches and team have noted the size (6-foot-6, 238 pounds) and physicality he brings to an offense that could use both. “That dude walks around, he looks like a tower over guys,” WR Malik Washington said. “So with his ability to catch the ball, his ability to run routes and his ability to block and be on his assignment, we’ve seen it in practice and stuff. I think adding him to the element, that just adds another playmaker to our team.” — Marcel Louis-Jacques

Stat to know: Both the Dolphins and Jets are 0-3 and have zero takeaways this season. It’s the first season since turnovers became official in 1933 that multiple teams are 0-3 with no takeaways. — ESPN Research

Bold prediction: Dolphins WR Tyreek Hill will record seven or more receptions, a season high. No team has faced more zone coverage this season than Miami (74% of the time), but the Jets are a man-heavy team that runs zone only 45% of the time. Over the past few seasons, Hill has had a higher target rate when facing man coverage. — Walder

Injuries: Jets | Dolphins

Fantasy nugget: Hall has had 12-plus touches in every game this season, including a season-high 21 in Week 1. The Jets’ offensive line ranks 14th in run block win rate (72.3%), while Miami’s defensive front sits 29th in run stop win rate (25.8%). The Dolphins have allowed the fifth-most fantasy points per game to running backs. Bills RB James Cook finished with 22 touches and 20.8 points in Week 3. Hall could replicate that performance in Week 4. See Week 4 rankings. — Moody

Betting nugget: The Jets are 22-33 ATS in prime-time games since 2005, including 5-13 ATS since 2019. Read more. — ESPN Research

Maldonado’s pick: Dolphins 30, Jets 14
Moody’s pick: Dolphins 30, Jets 26
Walder’s pick: Jets 20, Dolphins 17
FPI prediction: MIA, 54.9% (by an average of 2.1 points)

Matchup must-reads: Jets’ Fields returns to practice, will start if cleared … McDaniel: Dolphins better despite growing pains … Jets hoping for better production from struggling defense … Inside the Dolphins’ attempt to fix their locker room

Monday, 8:15 p.m. ET | ABC | Matchup rating: 56.1/100
ESPN BET: DEN, -7.5 (44.5 O/U)

What we’re hearing on the Bengals: This is not the week to be facing a strong Denver front, as the Bengals are once again trying to find a solution at right guard. Cincinnati rookie Jalen Rivers finished last week’s game at that spot in place of Dalton Risner, who is likely on the outside of that starting spot. That makes Rivers the fourth player giving it a shot (Lucas Patrick is currently on injured reserve with a calf injury). This is something to watch out for, as the Broncos’ Nik Bonitto is fourth in the league in pass rush win rate (29.8%) as an edge rusher. — Ben Baby

What we’re hearing on the Broncos: The Broncos certainly have emotional Band-Aids from back-to-back losses. On each game’s last play over the past two weeks, the defense couldn’t get the slam-the-door stops it needed. But in reality, the offense should bear the most scrutiny. The team is 27th in third-down conversions, 19th in offensive EPA and QB Bo Nix is 25th in QBR. And last week, the Broncos had seven — you read that right — possessions go for 10 or fewer yards. Four of those went for 1 yard, no gain or negative yardage. Toss in the fact the Broncos are the fourth-most penalized team in the league, and you have the recipe for a team that has yet to find the fast start coach Sean Payton tried to construct. — Jeff Legwold

Stat to know: Entering Week 4, the Broncos lead the league in pass block win rate (75%). The Bengals rank last in that category (45%). — ESPN Research

Bold prediction: Bengals RB Chase Brown will rush for at least 75 yards and a touchdown. Brown is overdue for a big production game (he had 3 rushing yards last week), and I think the Bengals’ offense with QB Jake Browning will look better in weeks when it isn’t facing the Vikings’ defense. — Walder

Injuries: Bengals | Broncos

Fantasy nugget: Nix has had a slow start to the season, scoring 20 fantasy points in just one game. The bright spot? His connection with WR Courtland Sutton, who has scored 18-plus fantasy points in two of three games. This duo now gets a Bengals secondary allowing the eighth-most passing yards per game (240.7). See Week 4 rankings. — Moody

Betting nugget: Nix is 8-2 ATS as a favorite. Read more. — ESPN Research

Maldonado’s pick: Broncos 20, Bengals 19
Moody’s pick: Broncos 33, Bengals 17
Walder’s pick: Bengals 23, Broncos 20
FPI prediction: DEN, 72.3% (by an average of 8.9 points)

Matchup must-reads: Without Burrow, Bengals can’t afford Brown’s woes … Three trends to explain the Broncos’ 1-2 start in 2025

Source link

Sep 19, 2025, 06:35 AM ET

The Week 3 NFL schedule for the 2025 season brings some intriguing matchups.

There are two battles between undefeated teams, with the Rams visiting the Eagles and the Cardinals facing the 49ers. Injuries have affected a few top QBs. The Bengals’ Joe Burrow (toe), the Vikings’ J.J. McCarthy (ankle) and the Jets’ Justin Fields (concussion) are ruled out, and the 49ers’ Brock Purdy (toe, shoulder) and the Commanders’ Jayden Daniels (knee) are listed as questionable. With that, their notable backups are looking to make their mark. On Sunday night, the Chiefs look to dig themselves out of their first 0-2 start with Patrick Mahomes against the Giants.

We have you covered with everything you need to know. Our NFL Nation reporters take you inside the locker room with the best thing they heard this week, and ESPN Research provides a key stat to know and a betting nugget for each contest. Plus, analytics writer Seth Walder makes a bold prediction for each matchup, and fantasy analyst Eric Moody shares fantasy football intel. We also have Football Power Index (FPI) matchup quality ratings (out of 100) and game projections, and three analysts — Pamela Maldonado, Moody and Walder — give us final score picks for every game.

Let’s get into the full Week 3 slate, which culminates with a “Monday Night Football” matchup between the Lions and Ravens on ESPN. (Game times are Sunday unless otherwise noted.)

Jump to a matchup:
LAR-PHI | GB-CLE | LV-WSH
CIN-MIN | HOU-JAX | PIT-NE
NYJ-TB | IND-TEN | ATL-CAR
DEN-LAC | NO-SEA | ARI-SF
DAL-CHI | KC-NYG | DET-BAL

Thursday: BUF 31, MIA 21

1 p.m. ET | Fox | Matchup rating: 77.7/100
ESPN BET: PHI -3.5 (44.5 O/U)

What we’re hearing on the Rams: The Eagles are the first team since 2010 to start a season 2-0 without a passing touchdown. Through two games, the Rams’ defense has allowed only one total touchdown. But despite the lack of passing touchdowns for QB Jalen Hurts and the Eagles, Rams coach Sean McVay called Hurts “a winner.” “He can beat you with his arm, legs or his mind,” McVay said. — Sarah Barshop

Editor’s Picks

2 Related

What we’re hearing on the Eagles: The Rams had a very difficult time against RB Saquon Barkley in their two matchups last season, as he racked up a whopping 460 yards on the ground against them in the regular season and in the playoffs. Even on the eight occasions they went with an eight-plus man box in the divisional matchup, Barkley had 92 yards and a touchdown, per NFL Next Gen Stats. “We do see opportunity when they load the box like that,” left tackle Jordan Mailata said. “It’s not a cockiness thing, it’s just based on the scheme that we have and also the guys up front, knowing that if we can get to these calls and execute them, huge gains.” — Tim McManus

Stat to know: Hurts has rushed for a touchdown in five straight games, including playoffs, which is tied for the longest streak of his career (five straight games from 2024 Weeks 7-11). — ESPN Research

Bold prediction: Barkley will record at least 25 rushing attempts. Not only are the Eagles a run-heavy team with a minus-9% pass rate over expectation (per NFL Next Gen Stats), but the Rams encourage runs against their defense. Teams facing the Rams have recorded a minus-11% pass rate over expectation, the third lowest of any defense. — Walder

Injuries: Rams | Eagles

Fantasy nugget: Rams QB Matthew Stafford has shown excellent rapport with WRs Puka Nacua and Davante Adams so far this season. And he has completed 15 passes that traveled 15 or more yards downfield. Facing an Eagles defensive front that’s ranked sixth with a 33.6% run stop win rate, the Rams would be wise to attack Philadelphia through the air. See Week 3 rankings. — Moody

Betting nugget: The Rams are 6-0 ATS (against the spread) in their past six road games. Read more. — ESPN Research

Maldonado’s pick: Rams 24, Eagles 20
Moody’s pick: Eagles 23, Rams 20
Walder’s pick: Eagles 28, Rams 24
FPI prediction: PHI, 57.1% (by an average of 3 points)

Matchup must-reads: How Nacua and Adams fit together in McVay’s offense … The Eagles offense is still figuring things out

1 p.m. ET | Fox | Matchup rating: 54.9/100
ESPN BET: GB -7.5 (41.5 O/U)

What we’re hearing on the Packers: Green Bay hasn’t gotten its running game going yet, and now it faces the No. 1 rushing defense in the league. The Browns have allowed only 92 rushing yards in their first two games. While RB Josh Jacobs has rushing touchdowns in each of the first two games (and has scored in a franchise record 10 straight dating to 2024), he averages only 3.6 yards per carry. “Obviously we all know what Josh did last year, so I think [for] teams, that’s kind of the game plan coming into it,” QB Jordan Love said. — Rob Demovsky

What we’re hearing on the Browns: This week, the Browns have said that they are “hyperaware” of Packers edge rusher Micah Parsons, who can rush from all over the defensive front. But limiting Parsons’ impact also means finding an effective run game that keeps Cleveland out of obvious passing situations. After playing 20 snaps and recording a game-high 61 rushing yards in his debut, rookie RB Quinshon Judkins is expected to get a greater workload in his second game. “He has the ability to kind of be a game breaker,” QB Joe Flacco said. — Daniel Oyefusi

Stat to know: On snaps that Parsons has played this season, the average opponent QBR is 14. When he’s off the field, the QBR jumps to 60. — ESPN Research

Bold prediction: Packers DT Karl Brooks will record a sack. Brooks typically lines up opposite the offense’s right side, and Browns G Wyatt Teller has the worst pass block win rate among guards (81.1%) in the league. Plus, having Parsons rushing the passer tends to generate sack opportunities for those around him. — Walder

play

0:50

Yates: Josh Jacobs a fantasy asset for the rest of the season

Field Yates breaks down the upside to Josh Jacobs and the Packers in fantasy this season.

Injuries: Packers | Browns

Fantasy nugget: Running back Jerome Ford led the Browns in snaps and targets in Week 2, but Judkins handled 10 rushing attempts despite missing all of camp and preseason. As mentioned, his early usage suggests he could lead the Browns’ backfield in touches in Week 3. See Week 3 rankings. — Moody

Betting nugget: The Browns are 7-15 ATS as underdogs over the past three seasons. Read more. — ESPN Research

Maldonado’s pick: Packers 35, Browns 10
Moody’s pick: Packers 27, Browns 13
Walder’s pick: Packers 26, Browns 6
FPI prediction: GB, 71% (by an average of 8.4 points)

Matchup must-reads: What Packers’ Watson extension means for ACL return … Packers rookie WR Golden not fazed by slow start … Browns not mulling QB change despite Flacco’s struggles … Why Judkins could be a ‘game breaker’ for struggling Browns’ offense

1 p.m. ET | CBS | Matchup rating: 49.8/100
ESPN BET: MIN -2.5 (41.5 O/U)

What we’re hearing on the Bengals: This could be the week the Bengals finally get their run game rolling, as they have the league’s worst rushing attack through two games. The Vikings are 26th in the league with 5.2 yards allowed per carry. If Cincinnati can be effective on the ground, that could help QB Jake Browning in his first start of the season. “[It] needs to be better,” offensive coordinator Dan Pitcher said. “No question. There are certainly things that we will investigate that we think can help that.” — Ben Baby

What we’re hearing on the Vikings: The Vikings have run a league-low 95 offensive plays this season, a fact coach Kevin O’Connell has repeatedly bemoaned as he has tried to find ways to use an array of talented skill players. One of the key reasons has been a 30.4% conversion rate on third down, the fourth lowest in the NFL. They might find more daylight against a Bengals defense that has been on the field for 151 plays this season, fourth most in the league. Cincinnati has also allowed the NFL’s third-highest third-down conversion rate (51.7%). — Kevin Seifert

Stat to know: Browning has a 71.5% career completion rate as a starter, which is the third-highest mark by any signal-caller in his first seven starts since QB starts were first tracked in 1950 (minimum 200 attempts), behind Jayden Daniels (75.6%) and Chad Pennington (73.7%). — ESPN Research

Bold prediction: Browning and Carson Wentz will each record a 60 QBR or higher. In both cases, the drop-off might not be as steep as expected. For Browning, it’s because of his track record (career 62 QBR and plus-3% completion percentage over expectation). For Wentz, it’s because of O’Connell, who gets the most out of his quarterbacks. (Remember Joshua Dobbs’ run in Minnesota in 2023?) — Walder

play

0:43

Why Stephen A. is worried for Jake Browning, Bengals

Stephen A. Smith says the Bengals’ offensive line is a major cause of concern.

Injuries: Bengals | Vikings

Fantasy nugget: Vikings RB Jordan Mason is set to handle most of the backfield work since Aaron Jones Sr. is sidelined by a hamstring injury. Mason is averaging 4.1 yards per carry behind an offensive line that ranks ninth in run block win rate (73.6%). The matchup is favorable, too, as the Bengals have given up the second-most fantasy points to running backs this season. See Week 3 rankings. — Moody

Betting nugget: Wentz is 27-38 ATS as a starter since 2018 (his third season). He is 3-6 ATS since 2022. Read more. — ESPN Research

Maldonado’s pick: Vikings 21, Bengals 17
Moody’s pick: Bengals 31, Vikings 27
Walder’s pick: Bengals 27, Vikings 20
FPI prediction: MIN, 55.6% (by an average of 2.2 points)

Matchup must-reads: Bengals sign QBs Clifford, White to practice squad … What does McCarthy’s injury mean for Vikings and his growth? … Bengals don’t blame OL for latest Burrow injury … Source: Vikings place Jones on injured reserve

1 p.m. ET | Fox | Matchup rating: 49.7/100
ESPN BET: WSH -3.5 (44.5 O/U)

What we’re hearing on the Raiders: Defensive tackle Jonah Laulu has been a pleasant surprise. Laulu, a 2024 seventh-rounder, has already totaled three sacks and four pressures through two games. Last season, he had only one sack in 17 games (seven starts). “He’s just blossomed,” coach Pete Carroll said. “He had enough plays on film coming off of last year that caught my eye. … He’s done a nice job. He’s been very active, been really consistent with his play.” — Ryan McFadden

What we’re hearing on the Commanders: Washington allowed Green Bay TE Tucker Kraft to catch six passes for 124 yards in Week 2 — and now it must face arguably the top player at that position in Brock Bowers. Defensive coordinator Joe Whitt Jr. said eye discipline was a key issue versus the Packers; too often, the Commanders lost sight of Kraft because of late motion or play-actions that fooled them. Washington will have to handle that much better versus Bowers, who lines up all over the field. “He’s a dynamic young tight end,” Whitt said. “You have to treat him like a receiver.” — John Keim

All of ESPN. All in one place.

Watch your favorite events in the newly enhanced ESPN App. Learn more about what plan is right for you. Sign Up Now

Stat to know: The Raiders’ defense has allowed 3.2 yards per rush this season — fourth fewest in the NFL. Meanwhile, the Commanders are averaging 5.3 yards per rush — third most. — ESPN Research

Bold prediction: Raiders QB Geno Smith will connect on multiple 30-plus air yard passes. Through two weeks, the Raiders have fun vertical routes 35% of the time — the second-highest rate in the league. And Smith has never been shy about taking some chances with his arm. — Walder

Injuries: Raiders | Commanders

Fantasy nugget: Commanders RB Jacory Croskey-Merritt appears to be the front-runner for the most touches in Washington’s backfield after Austin Ekeler tore his right Achilles in Week 2. The preseason standout has averaged 7.1 yards per carry on 14 attempts, and he’s firmly on the flex radar. The Commanders could lean on the run heavily since QB Jayden Daniels is dealing with a knee injury. See Week 3 rankings. — Moody

Betting nugget: The Raiders have covered six straight games on short rest. The Commanders are 11-29-1 ATS on short rest since 2013. Read more. — ESPN Research

Maldonado’s pick: Commanders 28, Raiders 20
Moody’s pick: Commanders 37, Raiders 31
Walder’s pick: Raiders 34, Commanders 31
FPI prediction: WSH, 60.6% (by an average of 4.7 points)

Matchup must-reads: Tom Brady did not violate rules in MNF game, NFL says … Commanders’ Daniels has knee injury, status iffy

1 p.m. ET | CBS | Matchup rating: 48.1/100
ESPN BET: JAX -1.5 (44.5 O/U)

What we’re hearing on the Texans: Texans QB C.J. Stroud said “we’re really close” to turning the season around after starting 0-2, pinpointing that Houston was “one or two plays away” from being 2-0. While that’s true, the offense has to score more than the 14 points per game it’s averaging. Watch to see how effective the offense is this week, because falling to 0-3 for the first time since 2020 could create a hole the Texans can’t get out of. — DJ Bien-Aime

What we’re hearing on the Jaguars: There isn’t a high level of concern about WR Brian Thomas Jr.’s slow start (five catches for 60 yards), but the Jaguars admit they have to get him going. Coach Liam Coen said he had a productive conversation with Thomas this week, and he has support from QB Trevor Lawrence, too. “Obviously we would’ve loved to start off hot these first two games and have our connection be ripping and me finding him everywhere and him having a great year and all those things,” Lawrence said. “But we’re in Week [3] everybody, so I think we can all just take a deep breath, give B.T. a little space. He’s going to be just fine.” — Michael DiRocco

Stat to know: Among 51 instances of a QB making at least five starts against a division opponent since 2021, Lawrence’s 39 Total QBR against the Texans (in eight starts) is the second lowest by any signal-caller versus a single division opponent (behind Zach Wilson’s 20 vs. the Patriots). — ESPN Research

Bold prediction: Jaguars WR/CB Travis Hunter will run more routes than WR Dyami Brown. This hasn’t been true in a game yet, but it would be a pretty awful sign for Hunter if he can’t surpass Brown on the depth chart quickly, considering the latter’s very unremarkable career to date. Brown has probably been a little better than expected (1.9 yards per route run, though his two drops sting), but Hunter should become the No. 2 guy in Jacksonville very soon. — Walder

Injuries: Texans | Jaguars

Fantasy nugget: The Texans’ defensive front might lead the league with a 56.8% pass rush win rate, but Houston ranks 24th with a 27.5% run stop win rate. That could push the Jaguars to lean on RBs Travis Etienne Jr. and Bhayshul Tuten. Jacksonville leads the league with 169.5 rushing yards per game behind an offensive line that ranks fifth with a 75.7% run block win rate. See Week 3 rankings. — Moody

Betting nugget: Unders are 13-6 in Texans games since the start of last season, the highest under rate in the NFL. Read more. — ESPN Research

Maldonado’s pick: Jaguars 27, Texans 20
Moody’s pick: Texans 20, Jaguars 14
Walder’s pick: Jaguars 24, Texans 20
FPI prediction: JAX, 52.9% (by an average of 1.5 points)

Matchup must-reads: Texans WR Kirk (hamstring) to play against Jaguars … Jaguars WR Thomas Jr. hopes to shake rough start … Jaguars release veteran safety Savage

1 p.m. ET | Fox | Matchup rating: 43.1/100
ESPN BET: TB -6.5 (43.5 O/U)

What we’re hearing on the Jets: The Jets have an enormous amount of confidence in veteran QB Tyrod Taylor, whom guard John Simpson described as “super swaggy.” Taylor, who replaces Justin Fields (concussion), has four touchdown passes and zero interceptions in three Jets appearances since 2024 — all mop-up duty. This will be his first start in 624 days (2023, Week 18). Taylor can be more effective from the pocket than Fields, but New York loses a lot without the threat of Fields’ running abilities. — Rich Cimini

What we’re hearing on the Buccaneers: The Bucs have now lost DT Calijah Kancey (pectoral) and G Cody Mauch (knee) for the season, while LT Tristan Wirfs is recovering from knee surgery and RT Luke Goedeke is expected to miss time with a foot injury. They’ve had to take the phrase “next man up” to a whole new level. G/C Ben Bredeson said of QB Baker Mayfield keeping the Bucs in games: “I think his leadership is incredible. There’s no one I’d rather follow in a two-minute drill. He goes in there with the utmost confidence and on fourth-and-10 is able to get out of something like that, scramble, get us a first down, pop up, lead the troops right down the field.” — Jenna Laine

Stat to know: WR Garrett Wilson has a 37% target share on the Jets offense this season. Only two players have had a target share that high in a full season: Brandon Marshall (Bears) in 2012 and Steve Smith Sr. (Panthers) in 2005. — ESPN Research

Bold prediction: Bucs LB SirVocea Dennis will lead the NFL in tackles this week. Among linebackers with at least 80 snaps played this season, Dennis ranks second in run stop win rate (53%) and is tied for eighth in tackle rate versus the run. There should be plenty of tackle opportunities against the run-heavy Jets. — Walder

play

2:05

Why Mark Schlereth loves Baker Mayfield’s journey in the NFL

Mark Schlereth joins the “The Rich Eisen Show” to express how impressed he is with Baker Mayfield’s career progression.

Injuries: Jets | Buccaneers

Fantasy nugget: Bucs WR Emeka Egbuka has had at least six targets and 13 fantasy points in both games this season. He reached 23.6 points in Week 1, but there’s a development in Week 2 that should excite fantasy managers. Egbuka played more snaps than Mike Evans and ran a similar number of routes. The Bucs are making an effort to use Egbuka both out wide and in the slot during two- or three-receiver sets. So the rookie is effectively a 1B to Evans’ 1A. See Week 3 rankings. — Moody

Betting nugget: The Jets are 19-39-1 ATS as road underdogs over the past decade (since 2016). Read more. — ESPN Research

Maldonado’s pick: Buccaneers 24, Jets 20
Moody’s pick: Buccaneers 34, Jets 19
Walder’s pick: Jets 20, Buccaneers 17
FPI prediction: TB, 70.1% (by an average of 8.4 points)

Matchup must-reads: Jets ‘have confidence’ in Taylor as starter vs. Bucs … Source: Buccaneers starting RG Mauch (knee) out for season … Sources: Bucs’ Kancey tore pec, to miss rest of season

1 p.m. ET | CBS | Matchup rating: 41.4/100
ESPN BET: PIT -1.5 (44.5 O/U)

What we’re hearing on the Steelers: Improving in the run game is an emphasis for the Steelers — on both sides of the ball. Through two games, the offense ranks 30th in yards per game (62.5) and yards per carry (3.0), while the defense is 28th in rushing yards per game allowed (149.5) and 22nd in yards per carry allowed (4.4). “We were getting knocked around a little bit last year,” said defensive coordinator Teryl Austin when asked if the run defense’s issues are similar to last year’s. “This year, we are not getting knocked around.” — Brooke Pryor

What we’re hearing on the Patriots: Starting CB Christian Gonzalez, who missed the first two games with a hamstring injury, was a limited participant in the first two practices of the week and thus has a chance to make his 2025 debut. If he does, a matchup against WR DK Metcalf (who experienced success against him in 2024) would loom large. “He’s a great receiver. He can change the game in a lot of ways — stretch the field, doing screens, doing a lot of things with him,” Gonzalez said. “I learned a lot from him last year and 1758290990 we’re focused on this year.” — Mike Reiss

Stat to know: The Steelers have allowed 31.5 points per game through the first two games of 2025, tied with 2018 for the most allowed through the opening two games under coach Mike Tomlin. — ESPN Research

Bold prediction: Patriots CB Carlton Davis III will record an interception. He has a strong 0.6 yards per coverage snap so far this season (average for an outside corner is 1.1). And if Gonzalez returns to action, he would push even more targets Davis’ way. — Walder

Breaking News from Adam Schefter

Download the ESPN app and enable Adam Schefter’s news alerts to receive push notifications for the latest updates first. Opt in by tapping the alerts bell in the top right corner. For more information, click here.

Injuries: Steelers | Patriots

Fantasy nugget: Patriots QB Drake Maye finished with 26.3 fantasy points in Week 2, showcasing his dual-threat ability and spreading the ball efficiently. He is well-positioned for success against a Steelers defense that has already allowed strong games to the Jets’ Justin Fields (29.5) and the Seahawks’ Sam Darnold (15.8). Like Fields, Maye should be able to exploit Pittsburgh on the ground. See Week 3 rankings. — Moody

Betting nugget: The Steelers are 0-2 ATS for the first time since 2019. They have not started 0-3 ATS since 2013. Read more. — ESPN Research

Maldonado’s pick: Steelers 27, Patriots 24
Moody’s pick: Patriots 23, Steelers 17
Walder’s pick: Steelers 22, Patriots 19
FPI prediction: PIT, 49.8% (by an average of 0.1 points)

Matchup must-reads: What we’re hearing entering Week 3: Latest on Rodgers … Steelers searching for the key to unlock their run game: ‘You’re looking to be efficient, explosive’ … Patriots’ Maye showed clear improvement at Miami … Steelers sign ex-Patriots LB Bentley to practice squad

1 p.m. ET | CBS | Matchup rating: 30.9/100
ESPN BET: IND -4.5 (43.5 O/U)

What we’re hearing on the Colts: The Colts might be 2-0, but they ranked 30th in defensive pressures (12) and 25th in sacks (3.0). This game might provide an opportunity to get the pass rush going. Tennessee has allowed a league-high 11 sacks and yielded 29 pressures (tied for sixth). The Colts are hoping to get defensive end Laiatu Latu, their 2024 first-round pick, back after he missed last Sunday’s game with a hamstring injury. — Stephen Holder

What we’re hearing on the Titans: RB Jonathan Taylor rushed for 218 yards the last time he saw the Titans, so they will need to be better this time around. A huge part of that will depend on DT T’Vondre Sweat’s status, as he is dealing with an ankle injury that kept him out last week. With Sweat in the lineup, the Titans’ run defense held opponents to 4.2 yards per carry (which would have been eighth fewest), but without him, those numbers bumped to 5.3 yards per carry (worst in the NFL). — Turron Davenport

Stat to know: Indianapolis is the first team in the Super Bowl era (since 1966) with zero punts through the first two games of the season. No team has gone three straight games without a punt since at least 1940. — ESPN Research

Bold prediction: Titans RB Tony Pollard will score his first touchdown of the season. Through two weeks, no running back is playing a higher percentage of their team’s offensive snaps than Pollard (89%). If the Titans have a scoring opportunity, there’s a good chance it will be with Pollard getting the ball. — Walder

play

0:51

Jonathan Taylor impressed with Daniel Jones as Colts QB

Jonathan Taylor joins “The Rich Eisen Show” to discuss what it is like having Daniel Jones as his quarterback.

Injuries: Colts | Titans

Fantasy nugget: Colts QB Daniel Jones scored 29.4 fantasy points in Week 1, then followed it up with 22.8 against a tough Broncos defense. His career renaissance could continue with a favorable matchup against a Titans defense that allowed Rams QB Matthew Stafford to finish with 298 passing yards and two touchdowns last week. Tennessee’s defensive front ranks 23rd in pass rush win rate (32.7%), so Jones should have plenty of time to throw. He’s a high-end QB2 this week. See Week 3 rankings. — Moody

Betting nugget: The Titans are 0-3 ATS as road favorites since the start of last season. Read more. — ESPN Research

Maldonado’s pick: Colts 33, Titans 13
Moody’s pick: Colts 24, Titans 13
Walder’s pick: Titans 20, Colts 16
FPI prediction: IND, 66% (by an average of 6.1 points)

Matchup must-reads: Jones-led offense spearheads Colts’ 2-0 start … Titans won’t cut Ward loose until run game improves … QB Ward, WR Ayomanor forming special bond for Titans

1 p.m. ET | Fox | Matchup rating: 29.9/100
ESPN BET: ATL -5.5 (44.5 O/U)

What we’re hearing on the Falcons: The Falcons had a goal to be the top offense in the league this season, but their defense has actually carried them thus far (outside of the terrific play of RB Bijan Robinson). Atlanta is 29th in the league in success rate in the red zone (26.1%), and offensive coordinator Zac Robinson acknowledged that “it’s definitely something we’ve gotta get fixed.” QB Michael Penix Jr. said he’s looking forward to the pass and run game clicking at the same time to “see how electric we can be.” — Marc Raimondi

What we’re hearing on the Panthers: QB Bryce Young had arguably the best performance of his career in the 2024 season finale against the Falcons, throwing for 252 yards and three touchdowns while rushing for two more. The key was that Atlanta never seriously pressured him, but things are different this week. Young is facing an Atlanta defense that found its groove last week with six sacks in a win over Minnesota. — David Newton

Stat to know: Young threw for career highs in completions (35), attempts (55) and passing yards (328) in Week 2. Young has never passed for 300-plus yards in consecutive games. — ESPN Research

Bold prediction: Robinson will record at least 50 rushing yards after contact. Not only is Robinson elusive, but the Panthers are allowing 2.5 yards after contact per carry, third most in the NFL. — Walder

Weekly NFL game expert picks

• Game picks from our NFL experts »
• Betting notes » | More NFL coverage »

Injuries: Falcons | Panthers

Fantasy nugget: The Falcons’ defense could be a smart pickup since it just put on a master class, forcing four turnovers and allowing just six points to Minnesota. Atlanta ranks eighth in run stop win rate (33.3%), which could force Young to throw more. Young has already been sacked four times and thrown three interceptions this season. See Week 3 rankings. — Moody

Betting nugget: The Panthers have covered five straight games as home underdogs. They are 8-2 ATS. Read more. — ESPN Research

Maldonado’s pick: Falcons 21, Panthers 14
Moody’s pick: Falcons 24, Panthers 17
Walder’s pick: Falcons 23, Panthers 21
FPI prediction: ATL, 56.4% (by an average of 2.6 points)

Matchup must-reads: Falcons’ Morris: Robinson definitely NFL’s best player … Hunt, Corbett injuries make Panthers’ failed comeback sting more … Falcons rookie defenders deliver big impact … Panthers to place Hunt, Corbett on IR

4:05 p.m. ET | CBS | Matchup rating: 70.6/100
ESPN BET: LAC -2.5 (45.5 O/U)

What we’re hearing on the Broncos: It will bear watching how effective the Broncos are in their attempts to make Chargers QB Justin Herbert uncomfortable in the pocket. After a six-sack performance against Titans rookie Cam Ward, the Broncos sent five or more rushers on 58% of Daniel Jones’ dropbacks last Sunday in Indianapolis. Denver sacked him only once and Jones finished with 316 passing yards. Herbert has faced the fifth-highest blitz rate in the league so far (37%), but he has a 72% completion rate with five touchdowns and zero interceptions behind plenty of heavy formations. The Broncos have to find a way to unsettle him. — Jeff Legwold

What we’re hearing on the Chargers: The Chargers swept Denver in two matchups last season, but this time they will have to be without edge rusher Khalil Mack, their team leader in QB pressures (five, tied with Tuli Tuipulotu). He was placed on injured reserve with an elbow injury after the win on Monday night but is not expected to be out for the season. “He’s like the Wolverine,” coach Jim Harbaugh said. “Toughest thing I’ve ever seen.” — Kris Rhim

Stat to know: According to ESPN Analytics/NFL Next Gen Stats, Broncos QB Bo Nix’s three interceptions this season have been versus zone coverage, tied with the Dolphins’ Tua Tagovailoa for the most. The Chargers have played zone coverage on 66% of opponent dropbacks, the sixth-highest mark this season. — ESPN Research

Bold prediction: Herbert will throw at least 37 pass attempts — yes, even against Pat Surtain II and the Broncos. The Chargers have the highest pass rate over expectation (plus-12%) so far this season, per NFL Next Gen Stats. — Walder

play

0:27

Justin Herbert: “All I gotta do is get him the ball”

Justin Herbert’s impressed with Keenan Allen’s offensive performance.

Injuries: Broncos | Chargers

Fantasy nugget: Herbert is spreading targets among Ladd McConkey (14), Quentin Johnston (14) and Keenan Allen (16) — all three are running a similar number of routes. Though that spread of wealth is not ideal for fantasy, each receiver remains a good start in most leagues. See Week 3 rankings. — Moody

Betting nugget: The Broncos are 5-1 ATS in their past six games following a loss. Read more. — ESPN Research

Maldonado’s pick: Chargers 16, Broncos 10
Moody’s pick: Chargers 27, Broncos 23
Walder’s pick: Chargers 30, Broncos 20
FPI prediction: LAC, 56% (by an average of 2.5 points)

Matchup must-reads: Broncos need more defensive stability, better run stopping … How Chargers’ WR corps went from Achilles heel to a strength

4:05 p.m. ET | CBS | Matchup rating: 31.7/100
ESPN BET: SEA -7.5 (41.5 O/U)

What we’re hearing on the Saints: Saints QB Spencer Rattler is coming off the best game of his career, in which he threw three touchdown passes. However, Rattler is still searching for his first win and is 0-8 as a starter. This will be his fourth career road start, and he said the theme this week is “be poised in the noise,” with the team acknowledging that playing in Seattle will be a challenge. To prepare, coach Kellen Moore had officials at practice again and said he planned to have speakers simulate the noise from the stadium. The Saints will also travel to Seattle early to practice there Friday. — Katherine Terrell

What we’re hearing on the Seahawks: The Seahawks are home favorites, but they don’t need any reminders about the dangers of a letdown game. Last October, they lost 29-20 to a Giants team that also came to Lumen Field as 7.5-point underdogs. “I think that ‘Any given Sunday’ quote is something that’s just so real and believable in this league,” veteran DT Leonard Williams said. “Literally any week, any team can win. So you never want to overlook a team.” — Brady Henderson

Stat to know: Seahawks WR Jaxon Smith-Njigba is seeking to become the first player in franchise history with three straight games of 100-plus receiving yards to begin a season. — ESPN Research

Bold prediction: The Seahawks will sack Rattler six or more times in a win. Through two games, Seattle’s pass rush has been a bright spot, ranking third in pass rush win rate (49.1%). — Walder

play

1:04

Could the Seahawks win the NFC West?

Dan Orlovsky joins “Get Up” to break down why the Seattle Seahawks have a legitimate shot at winning the NFC West this season.

Injuries: Saints | Seahawks

Fantasy nugget: Saints TE Juwan Johnson has stockpiled 20 targets this season, scoring at least 15 fantasy points in both games. He has played 97.8% of the Saints’ offensive snaps and run 74 routes, the most of any tight end in the league. This season, no defense has given up more fantasy points to tight ends than the Seahawks. See Week 3 rankings. — Moody

Betting nugget: The Saints are 1-5 ATS in their past six road games. Read more. — ESPN Research

Maldonado’s pick: Seahawks 34, Saints 10
Moody’s pick: Seahawks 31, Saints 20
Walder’s pick: Seahawks 27, Saints 13
FPI prediction: SEA, 65.5% (by an average of 5.9 points)

Matchup must-reads: Where does Saints QB Shough land in our backup QB rankings? … QB Darnold showed what Seahawks offense can do … Saints look for positives despite first 0-2 start since 2017

4:25 p.m. ET | Fox | Matchup rating: 60.6/100
ESPN BET: SF -2.5 (44.5 O/U)

What we’re hearing on the Cardinals: Though the Cardinals are off to a 2-0 start for the third time in the past six seasons, second-year WR Marvin Harrison Jr. isn’t off to the start he was hoping for. Through two games, he has seven catches on 11 targets for 98 yards and a touchdown. Harrison isn’t happy he’s not having more of an impact on the offense — and he’s not the only one. Coach Jonathan Gannon said Arizona needs more production from Harrison. “It’s always frustrating when you may not get the impact that you kind of want in the game, especially when you put in so much work,” Harrison said. — Josh Weinfuss

What we’re hearing on the 49ers: Corralling Cardinals QB Kyler Murray has always been a battle for the 49ers. Murray is 4-4 in his eight starts against San Francisco, and his ability to make plays with his legs has been an issue in most of those games. “The ability to make the off-schedule plays, that’s always kind of given us fits,” LB Fred Warner said. “We’re going to try to do our best to try to contain him, but at the end of the day, he’s going to make his plays. We’ve got to just limit the damage.” Murray has averaged 52.8 rushing yards per game against the Niners in his career, his second-highest mark against any team he has played more than twice. — Nick Wagoner

Stat to know: The Cardinals are 2-0 this season despite being outgained by at least 25 yards in each game. The 2020 Seahawks are the only team this century to start a season 3-0 while being outgained by at least 25 yards in each game. — ESPN Research

Best of NFL Nation

• Eberflus not looking for revenge
• Why Jenkins could be a ‘game-breaker’
• Steelers can’t unlock run game
• Injury impact on J.J. McCarthy, Vikings
• Packers’ Golden unfazed by slow start
• Eagles offense still figuring it out

Bold prediction: 49ers WR Kendrick Bourne will record six or more receptions. Bourne played 49% of San Francisco’s offensive snaps in his first game back with the team last week. I have to imagine that number will steadily rise. — Walder

Injuries: Cardinals | 49ers

Fantasy nugget: Niners QB Mac Jones is in a good spot this week, especially for managers in desperate need of a streamer because of injuries. Arizona has allowed the seventh-most passing yards per game (255.5) this season. See Week 3 rankings. — Moody

Betting nugget: The Cardinals have covered five straight games as underdogs. Read more. — ESPN Research

Maldonado’s pick: 49ers 27, Cardinals 22
Moody’s pick: 49ers 24, Cardinals 21
Walder’s pick: Cardinals 27, 49ers 19
FPI prediction: ARI, 51.5% (by an average of 0.7 points)

Matchup must-reads: Cardinals place CB Williams on IR with knee injury … Saleh’s 49ers defense instrumental in 2-0 start … 2-0 Cards know they must clean up ‘sloppy’ ball

4:25 p.m. ET | Fox | Matchup rating: 46.9/100
ESPN BET: DAL -1.5 (50.5 O/U)

What we’re hearing on the Cowboys: QB Dak Prescott’s start to the season has been impressive. It’s not just the raw numbers — 549 yards, which would be more without five drops — either. He is also completing 75% of his passes on third down and 64% of his passes when pressured. “I think he’s playing how we would expect him to play. We have a high standard for Dak and the way he’s supposed to perform,” coach Brian Schottenheimer said. “I think there’s a confidence about him right now, which is great.” — Todd Archer

What we’re hearing on the Bears: Former Bears coach Matt Eberflus is returning to Soldier Field as the Cowboys’ defensive coordinator. There’s probably no other coach who knows as much about QB Caleb Williams’ tendencies and ways to attack them than Eberflus, but Williams views this chess match the way he would with any other defensive coordinator. Coach Ben Johnson, on the other hand, picked the brains of people inside Halas Hall to get information on Eberflus’ schematic tendencies and how he approached Johnson’s offenses in Detroit. “I feel like we know what he knows, and we’ll be just fine there,” Johnson said. — Courtney Cronin

Stat to know: Prescott is seeking his 18th game (and second straight) with 350 passing yards and two touchdown throws. If he achieves this feat, Prescott would pass Tom Brady for second most in the NFL since 2016 (behind Patrick Mahomes’ 21). — ESPN Research

Bold prediction: The Bears will score 30-plus points. Here’s a number that stands out to me: Chicago ranks fifth in expected completed air yards per attempt (5.9). That’s a mouthful, I know. But that number indicates the play designs are working. Against Dallas, I could see it coming together for some offensive fireworks. — Walder

play

1:32

Stephen A. confused by Ben Johnson’s comments on Bears’ habits

Stephen A. Smith reacts to Bears coach Ben Johnson’s comments about their practice habits not being good enough.

Injuries: Cowboys | Bears

Fantasy nugget: Williams finished with just 17 fantasy points against Detroit, but he connected with seven different receivers throughout the afternoon. He showed excellent chemistry with WR Rome Odunze, who finished with 31.8 fantasy points on seven receptions. Now, Williams faces a Cowboys defense that gave up 30.2 fantasy points to the Giants’ Russell Wilson last week. See Week 3 rankings. — Moody

Betting nugget: The Cowboys are 4-1 ATS in their past five games as underdogs. Read more. — ESPN Research

Maldonado’s pick: Bears 27, Cowboys 24
Moody’s pick: Cowboys 38, Bears 28
Walder’s pick: Bears 34, Cowboys 24
FPI prediction: DAL, 53.3% (by an average of 1.5 points)

Matchup must-reads: Cowboys think Smith can be ‘one of the greats’ … Defense not producing as Bears search for first win … Johnson: Bears’ practice habits not ‘championship-caliber’ … Cowboys DC Eberflus not seeking revenge against Bears

8:20 p.m. ET | NBC | Matchup rating: 54.2/100
ESPN BET: KC -6.5 (45.5 O/U)

What we’re hearing on the Chiefs: One key factor for the Chiefs’ defense will be taking the ball away, as they haven’t done that all season. “Turnovers affect the game,” DT Chris Jones said. “It can completely change the game. As a defense, we have to find ways to create more turnovers and give the ball back to [QB Patrick Mahomes] and coach [Andy] Reid. If we give the ball back to them, points will be generated.” Since the Chiefs’ offense has struggled, a pivotal highlight from the defense could be what sparks Mahomes and the offense to score enough points for the first victory of the season. — Nate Taylor

What we’re hearing on the Giants: Just because the Chiefs are 0-2 doesn’t mean the Giants look at them any differently than a Super Bowl contender. DL Dexter Lawrence II chuckled at the idea that they have slipped, noting Kansas City still has most of its core players and the “best of the best” in Mahomes. The Chiefs are still among the league’s best teams despite their record, according to Lawrence. “That just don’t disappear,” he said. — Jordan Raanan

Stat to know: With a passing and rushing touchdown in both games, Mahomes is looking to become the third quarterback in NFL history to record a TD run and pass in the first three games of a season. He’d join Jack Kemp (1965) and Kyler Murray (2020). — ESPN Research

Bold prediction: The Chiefs will record positive EPA (expected points added) per designed carry. That would be a huge step for them, considering they are averaging minus-0.1 EPA per carry. But the Giants’ defense ranks second worst in EPA allowed per designed carry (0.17), so that could quell the ills of the Kansas City ground attack. — Walder

play

1:24

How concerning are the Chiefs’ early offensive struggles?

Dan Orlovsky breaks down why he is “not confident” the Chiefs can get their offense back on track this season.

Injuries: Chiefs | Giants

Fantasy nugget: In Week 2, the Giants’ Russell Wilson became just the sixth QB to throw for 400 yards with three different teams. Wide receiver Malik Nabers’ 238 receiving yards through two games were the most by a Giants player since 1984. Nabers is a must-start this week, while Wilson is a viable streamer. But don’t sleep on WR Wan’Dale Robinson, who finished with 10 targets and 28.2 points in Week 2. See Week 3 rankings. — Moody

Betting nugget: Wilson is 18-8 ATS in his career as an underdog of at least four points. Read more. — ESPN Research

Maldonado’s pick: Chiefs 20, Giants 10
Moody’s pick: Chiefs 27, Giants 20
Walder’s pick: Chiefs 23, Giants 20
FPI prediction: KC, 65.2% (by an average of 6.3 points)

Matchup must-reads: Worthy practices in full, hopes to play vs. Giants … Giants QB2 Dart following in Mahomes’ rookie footsteps

Monday, 8:15 p.m. ET | ESPN | Matchup rating: 90.1/100
ESPN BET: BAL -4.5 (53.5 O/U)

What we’re hearing on the Lions: Although it was two seasons ago, the Lions haven’t forgotten about their last meeting in Baltimore — an embarrassing 38-6 loss in 2023. “You don’t forget those because we didn’t even give ourselves a chance,” coach Dan Campbell said. Coming off a dominant win, Detroit is preparing to match that physical nature against the Ravens, but feels more prepared this time around. “The physicality of this game is gonna be high. We know that,” said receivers coach Scottie Montgomery. “And that’s what we have to accept, and we have to do a lot better than we did last time.” — Eric Woodyard

What we’re hearing on the Ravens: Ravens QB Lamar Jackson doesn’t like to talk about his remarkable record against the NFC because it could jinx it. Jackson is 24-2 against the conference, which is the best mark by any starting quarterback in interconference games since the AFC and NFC were created in 1970. He is 2-0 against the Lions, totaling five touchdowns and one interception. His dominance over the NFC shows that it’s difficult to beat Jackson and his unpredictable playing style when you don’t face him regularly. — Jamison Hensley

Stat to know: Over the first two games of the season, Jackson and Lions QB Jared Goff are tied for the most passing TDs in the NFL, at six each. — ESPN Research

Bold prediction: Lions CB Terrion Arnold will allow at least 80 yards and a touchdown to WRs Zay Flowers and Rashod Bateman, combined. Arnold has allowed 3.2 yards per coverage snap as the nearest defender — highest in the league among outside corners with at least 50 coverage snaps — per NFL Next Gen Stats. — Walder

Play the No. 1 fantasy game

The season has kicked off but there’s still time to start fresh with a 0-0 record. Create a league with friends and family, or join a public league. Your championship run starts today! Sign Up Now >>

Injuries: Lions | Ravens

Fantasy nugget: Flowers has a 42.6% team target share this season. The only other receiver with a share over 40% is the Seahawks’ Jaxon Smith-Njigba. Flowers recorded nine or more targets and 15-plus fantasy points in both games this season. He’ll be busy again, as this matchup has one of the highest totals on the slate. See Week 3 rankings. — Moody

Betting nugget: This is the third game this season with an over/under that’s higher than 50 points (Ravens-Bills: 51.5, Jaguars-Bengals: 50.5). The previous two both went over the total. Read more. — ESPN Research

Maldonado’s pick: Ravens 30, Lions 23
Moody’s pick: Ravens 31, Lions 28
Walder’s pick: Ravens 34, Lions 20
FPI prediction: BAL, 57.3% (by an average of 2.7 points)

Matchup must-reads: Lions extend win streak after losses to 11, turn eyes toward Baltimore … Is it too early to consider Jackson on an MVP arc?

Source link